Results 91 to 100 of about 604,199 (244)

Resolving the disk rotation of HD 97048 and HD 100546 in the [O I] 6300A line: evidence for a giant planet orbiting HD 100546

, 2005
Aims. We intend to spatially and spectrally resolve the [O I] emission region in two nearby Herbig stars. Methods. We present high-resolution (R = 80,000) VLT/UVES echelle spectra of the [O I] 6300A line in the Herbig Ae/Be stars HD 97048 and HD 100546.
Acke, Acke, Acke, Acke, Armitage, Artymowicz, Augereau, B. Acke, Boss, Bouwman, Chiang, Deleuil, Dominik, Dullemond, Eggleton, Grady, Grady, Hill, Leinert, Liu, M. E. van den Ancker, Malfait, McCarthy, Oppenheimer, Pantin, Quillen, van Boekel, van den Ancker, Wilner   +28 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Efficient Modeling of Underwater Target Radiation and Propagation Sound Field in Ocean Acoustic Environments Based on Modal Equivalent Sources

Journal of Marine Science and Engineering
The equivalent source method (ESM) is a core algorithm in integrated radiation-propagation acoustic field modeling. However, in challenging marine environments, including deep-sea and polar regions, where sound speed profiles exhibit strong vertical ...
Yan Lv, Wei Gao, Xiaolei Li, Haozhong Wang, Shoudong Wang   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Neuroimaging Studies Of Striatum In Cognition, Part I: Healthy Individuals

Frontiers in Systems Neuroscience, 2015
The striatum has traditionally mainly been associated with playing a key role in the modulation of motor functions. Indeed, lesion studies in animals and studies of some neurological conditions in humans have brought further evidence to this idea ...
Jean-Sebastien eProvost, Alexandru eHanganu, Alexandru eHanganu, Oury eMonchi, Oury eMonchi   +4 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

RCEMIP-II: mock-Walker simulations as phase II of the radiative–convective equilibrium model intercomparison project [PDF]

Geoscientific Model Development
The radiative–convective equilibrium (RCE) model intercomparison project (RCEMIP) leveraged the simplicity of RCE to focus attention on moist convective processes and their interactions with radiation and circulation across a wide range of model types ...
A. A. Wing, L. G. Silvers, L. G. Silvers, K. A. Reed   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Stimulus-category competition, inhibition and affective devaluation: A novel account of the Uncanny Valley

Frontiers in Psychology, 2015
Stimuli that resemble humans, but are not perfectly human-like, are disliked compared to distinctly human and nonhuman stimuli. Accounts of this Uncanny Valley effect often focus on how changes in human resemblance can evoke different emotional responses.
Anne E. Ferrey, Tyler J. Burleigh, Mark J. Fenske   +2 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source