Results 91 to 100 of about 430,778 (289)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

3D Sensitivity Kernels With Full Attenuation Computed by a Combination of the Strong Stability Preserving Runge‐Kutta Method and the Scattering‐Integral Method [PDF]

, 2023
Nian Wang, Dinghui Yang, Yang Shen, Xueyang Bao, Jiahang Li   +4 more
openalex   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Positivity-Preserving Finite Difference WENO Schemes with Constrained Transport for Ideal Magnetohydrodynamic Equations [PDF]

, 2015
In this paper, we utilize the maximum-principle-preserving flux limiting technique, originally designed for high order weighted essentially non-oscillatory (WENO) methods for scalar hyperbolic conservation laws, to develop a class of high order ...
Christlieb, Andrew J., Liu, Yuan, Tang, Qi, Xu, Zhengfu   +3 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Soy protein isolate-pectin from Nicandra Physaloides (Linn.) Gaertn seeds nanogels: A hydrocolloid system for blueberry preservation

Food Chemistry: X
Resveratrol (Res) and Phloretin (Pht) are natural compounds with antioxidant and anti-inflammatory activities, yet their practical applications face certain limitations.
Dan Meng, Wenqi Yang, Zhong Zhang, Xiaoyu Wang, Jianke Li, Li Yuan   +5 more
doaj   +1 more source

Quasi One-Dimensional Model of Natural Draft Wet-Cooling Tower Flow, Heat and Mass Transfer

EPJ Web of Conferences, 2015
The article deals with the development of CFD (Computational Fluid Dynamics) model of natural draft wet-cooling tower flow, heat and mass transfer. The moist air flow is described by the system of conservation laws along with additional equations.
Hyhlík Tomáš
doaj   +1 more source

High order strong stability preserving multi-derivative implicit and IMEX Runge--Kutta methods with asymptotic preserving properties [PDF]

, 2021
Sigal Gottlieb, Zachary J. Grant, J. Y. Hu, Ruiwen Shu   +3 more
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effect of Preservatives and Storage Temperature on the Quality and Antioxidant Stability of Snake Fruit Peel Tea Drink [PDF]

BIO Web of Conferences
Salak is a tropical fruit that is widely found in Indonesia, the skin of the snake fruit which has been considered waste turns out to have health benefits.
Sholihah Ni’matus, Hidayat Jefri Pandu, Kumalaningrum Amalia Nur, Herlina Farrah Widy, Jannah Raudhatul, Nofianti Alya   +5 more
doaj   +1 more source