Results 51 to 60 of about 2,005 (214)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Rings in which Every Simple Right R-Module is Flat [PDF]
Al-Rafidain Journal of Computer Sciences and Mathematics, 2004 The objective of this paper is to initiate the study of rings in which each simple right R-module is flat, such rings will be called right SF-rings. Some important properties of right SF-rings are obtained.
Raida Mahmood
doaj +1 more source
Strongly Regular Semi-Cayley Graphs [PDF]
Journal of Algebraic Combinatorics, 1992 This paper studies strongly regular graphs \(G\) on \(2n\) vertices which admit a group of automorphisms \(\Gamma\) of order \(n\) with two orbits of length \(n\) on the vertices of \(G\), which are called semi-Cayley graphs. The Petersen and Hoffman-Singleton graphs provide examples.
de Resmini, Marialuisa J. +1 more
openaire +3 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
On the U-WPF Acts over Monoids [PDF]
Journal of Sciences, Islamic Republic of Iran, 2007 Valdis Laan in [5] introduced an extension of strong flatness which is called weak pullback flatness. In this paper we introduce a new property of acts over monoids, called U-WPF which is an extension of weak pullback flatness and give a classification ...
A. Golchin
doaj
Al-Rafidain Journal of Computer Sciences and Mathematics, 2007 The purpose of this paper is to study a new class of rings R in which, for each a Î R, aÎ aR aR, for some positive integer n. Such rings are called sp-weakly regular rings and give some of their basic properties as well as the relation between sp-weakly
Raida Mahmood, Abdullah Abdul-Jabbar
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A spectral excess theorem for digraphs with normal Laplacian matrices [PDF]
Transactions on Combinatorics, 2018 The spectral excess theorem, due to Fiol and Garriga in 1997, is an important result, because it gives a good characterization of distance-regularity in graphs. Up to now, some authors have given some variations of this theorem.
Fateme Shafiei
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source