Results 71 to 80 of about 2,811,422 (296)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Fuzzy $e$-regular spaces and strongly $e$-irresolute mappings [PDF]
Sahand Communications in Mathematical Analysis, 2018 The aim of this paper is to introduce fuzzy ($e$, almost) $e^{*}$-regular spaces in $check{S}$ostak's fuzzy topological spaces. Using the $r$-fuzzy $e$-closed sets, we define $r$-($r$-$theta$-, $r$-$etheta$-) $e$-cluster points and their properties ...
Veerappan Chandrasekar +1 more
doaj +1 more source
Disconnecting strongly regular graphs
European Journal of Combinatorics, 2014 In this paper, we show that the minimum number of vertices whose removal disconnects a connected strongly regular graph into non-singleton components, equals the size of the neighborhood of an edge for many graphs. These include blocks graphs of Steiner $2$-designs, many Latin square graphs and strongly regular graphs whose intersection parameters are ...
Sebastian M. Cioaba +2 more
openaire +4 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Strongly Regular Extensions of Rings [PDF]
Nagoya Mathematical Journal, 1962 As defined by Arens and Kaplansky [2] a ring A is strongly regular (s.r.) in case to each a∊ A there corresponds x = xa ∊A depending on a such that a 2 x = a. In the present article a ring A is defined to be a s.r.
openaire +2 more sources
Strongly Regular Graphs with Maximal Energy [PDF]
The energy of a graph is the sum of the absolute values of the eigenvalues of its adjacency matrix. Koolen and Moulton have proved that the energy of a graph on n vertices is at most n(1 + √n)/2, and that equality holds if and only if the graph is ...
Haemers, W.H.
core
Strongly regular (alpha,beta)-geometries [PDF]
, 2001 In this paper we introduce strongly regular (alpha, beta)-geometries. These are a class of geometries that generalise semipartial geometries. Like semipartial geometries the underlying point graph is strongly regular and this is part of the motivation ...
Hamilton, Nicholas +3 more
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Hamiltonian Strongly Regular Graphs [PDF]
We give a sufficient condition for a distance-regular graph to be Hamiltonian. In particular, the Petersen graph is the only connected non-Hamiltonian strongly regular graph on fewer than 99 vertices.Distance-regular graphs;Hamilton cycles JEL ...
Brouwer, A.E., Haemers, W.H.
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source