Results 61 to 70 of about 40,584 (295)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
More on Signed Graphs with at Most Three Eigenvalues
Discussiones Mathematicae Graph Theory, 2022 We consider signed graphs with just 2 or 3 distinct eigenvalues, in particular (i) those with at least one simple eigenvalue, and (ii) those with vertex-deleted subgraphs which themselves have at most 3 distinct eigenvalues.
Ramezani Farzaneh +2 more
doaj +1 more source
Co-cliques and star complements in extremal strongly regular graphs [PDF]
, 2006 Suppose that the positive integer μ is the eigenvalue of largest multiplicity in an extremal strongly regular graph G. By interlacing, the independence number of G is at most 4μ2 + 4μ - 2.
Rowlinson, Peter +2 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
On Strongly Regular Graphs withμ= 1
European Journal of Combinatorics, 2001 The paper looks at strongly regular graphs in which each pair of non-adjacent vertices has exactly one common neighbour. Relationships between the parameters of such graphs are explored as are some of the associated particle linear spaces and distance-regular graphs.
J. Deutsch, P. H. Fisher
openaire +1 more source
The uniqueness of the strongly regular graph on $77$ points [PDF]
, 1983 We show the uniqueness of the strongly regular graph with parameters ¿ = 77, k = 16, ¿ = O, µ = 4 embedding it in the Higman-Sims graph as a second subconstituent, and indicate the existence of a sporadic ...
A. E. Brouwer +3 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The real equiangular tight frames obtained from rank 3 graphs
Electronic Journal of Graph Theory and ApplicationsWe present all nontrivial real equiangular tight frames {φm}m=1M in RN obtained as spherical embeddings of primitive rank 3 graphs on M vertices, and those such that one of their associated M strongly regular graphs on M - 1 vertices is a primitive rank ...
Eiichi Bannai +4 more
doaj +1 more source
Rotation-based schedules in elementary schools to prevent COVID-19 spread: a simulation study
Scientific Reports, 2023 Rotations of schoolchildren were considered as a non-pharmacological intervention in the COVID-19 pandemic. This study investigates the impact of different rotation and testing schedules.We built an agent-based model of interactions among pupils and ...
Cyril Brom +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source