Results 71 to 80 of about 3,100,536 (300)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The real equiangular tight frames obtained from rank 3 graphs

Electronic Journal of Graph Theory and Applications
We present all nontrivial real equiangular tight frames {φm}m=1M in RN obtained as spherical embeddings of primitive rank 3 graphs on M vertices, and those such that one of their associated M strongly regular graphs on M - 1 vertices is a primitive rank ...
Eiichi Bannai, Etsuko Bannai, Chin-Yen Lee, Hajime Tanaka, Wei-Hsuan Yu   +4 more
doaj   +1 more source

More on Signed Graphs with at Most Three Eigenvalues

Discussiones Mathematicae Graph Theory, 2022
We consider signed graphs with just 2 or 3 distinct eigenvalues, in particular (i) those with at least one simple eigenvalue, and (ii) those with vertex-deleted subgraphs which themselves have at most 3 distinct eigenvalues.
Ramezani Farzaneh, Rowlinson Peter, Stanić Zoran   +2 more
doaj   +1 more source

Feasibility conditions on the parameters of a strongly regular graph [PDF]

, 2011
We consider a strongly regular graph, G, and associate a three dimensional Euclidean Jordan algebra, V, to the adjacency matrix A of G. Then, by considering convergent series of Hadamard powers of the idempotents of the unique complete system of ...
Vasco Moço Mano, Mano, Vasco Moço, Martins, Enide Andrade, Luís António de Almeida Vieira, Vieira, Luís António de Almeida, Enide Andrade Martins   +5 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Unavoidable parallel minors of regular matroids [PDF]

, 2011
This is the post-print version of the Article - Copyright @ 2011 ElsevierWe prove that, for each positive integer k, every sufficiently large 3-connected regular matroid has a parallel minor isomorphic to M (K_{3,k}), M(W_k), M(K_k), the cycle matroid of
Chun, Carolyn, Oxley, James, Oxley, J, Carolyn Chun, James Oxley, Chun, C   +5 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

On Strongly Regular Graphs withμ= 1

European Journal of Combinatorics, 2001
The paper looks at strongly regular graphs in which each pair of non-adjacent vertices has exactly one common neighbour. Relationships between the parameters of such graphs are explored as are some of the associated particle linear spaces and distance-regular graphs.
J. Deutsch, P. H. Fisher
openaire   +2 more sources

Co-cliques and star complements in extremal strongly regular graphs [PDF]

, 2006
Suppose that the positive integer μ is the eigenvalue of largest multiplicity in an extremal strongly regular graph G. By interlacing, the independence number of G is at most 4μ2 + 4μ - 2.
Rowlinson, Peter, P. Rowlinson
core   +1 more source