Results 71 to 80 of about 2,975,002 (298)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Some Implications on Amorphic Association Schemes [PDF]
AMS classifications: 05E30, 05B20;amorphic association scheme;strongly regular graph;(negative) Latin square type;cyclotomic association scheme;strongly regular ...
Dam, E.R. van, Muzychuk, M.
core +2 more sources
On Strongly Regular Graphs and the Friendship Theorem
MathematicsThis paper presents an alternative proof of the celebrated friendship theorem, originally established by Erdős, Rényi, and Sós in 1966. The proof relies on a closed-form expression for the Lovász ϑ-function of strongly regular graphs, recently derived by
Igal Sason
doaj +1 more source
International Journal of Mathematics and Mathematical Sciences, 1985 In this paper we define a topological space X to be θ-regular if every filterbase in X with a nonempty θ-adherence has a nonempty adherence. It is shown that the class of θ-regular topological spaces includes rim-compact topological spaces and that θ ...
Dragan S. Janković
doaj +1 more source
Rotation-based schedules in elementary schools to prevent COVID-19 spread: a simulation study
Scientific Reports, 2023 Rotations of schoolchildren were considered as a non-pharmacological intervention in the COVID-19 pandemic. This study investigates the impact of different rotation and testing schedules.We built an agent-based model of interactions among pupils and ...
Cyril Brom +10 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
On the locating matrix of a graph and its spectral analysis [PDF]
Computer Science Journal of Moldova, 2017 We introduce a new matrix representation for a graph by defining the locating matrix $\mathbf{Lo}(G)$ of $G$. We define the locating eigenvalues, the locating spectrum, and locating energy of the graph and we calculate them for some standard graphs.
H. N. Ramaswamy +2 more
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Regular graphs with four eigenvalues [PDF]
We study the connected regular graphs with four distinct eigenvalues. Properties and feasibility conditions of the eigenvalues are found. Several examples, constructions and characterizations are given, as well as some uniqueness and nonexistence results.
Dam, E.R. van
core +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source