Results 71 to 80 of about 370,627 (270)

The asymptotics of strongly regular graphs [PDF]

open access: yes, 2004
A strongly regular graph is called trivial if it or its complement is a union of disjoint cliques. We prove that every infinite family of nontrivial strongly regular graphs is quasi-random in the sense of Chung, Graham and ...
Nikiforov, Vladimir
core  

New bounds for the max-$k$-cut and chromatic number of a graph

open access: yes, 2015
We consider several semidefinite programming relaxations for the max-$k$-cut problem, with increasing complexity. The optimal solution of the weakest presented semidefinite programming relaxation has a closed form expression that includes the largest ...
Sotirov, Renata, van Dam, Edwin R.
core   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

The Cayley graph built upon the semigroup of left ideals of a ring

open access: yes上海师范大学学报. 自然科学版, 2014
We investigate the interaction between a ring R and the Cayley graph Cay(L(R)) of the semigroup of left ideals of R,as well as subdigraphs of this graph.Graph theoretic properties of these graphs are investigated,such as transitive closure,girth,radius ...
Aihua Li, Ralph P.Tucci
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

rc-continuous functions and functions with rc-strongly closed graph

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2003
The family of regular closed subsets of a topological space is used to introduce two concepts concerning a function f from a space X to a space Y. The first of them is the notion of f being rc-continuous.
Bassam Al-Nashef
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Strongly Regular Graphs with Parameters (4m4, 2m4 + m2, m4 + m2, m4 + m2) Exist for All m>1 [PDF]

open access: yes
Using results on Hadamard difference sets, we construct regular graphical Hadamard matrices of negative type of order 4m4 for every positive integer m. If m > 1, such a Hadamard matrix is equivalent to a strongly regular graph with parameters (4m4, 2m4 ...
Haemers, W.H., Xiang, Q.
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

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