Results 111 to 120 of about 965,004 (336)

Economic Impact of the Mid-Term Review on Agricultural Production, Farm Income and Farm Survival: A Quantitative Analysis for Local Sub-Regions of Schleswig-Holstein in Germany [PDF]

This study analyzes the impact of the Mid-Term Review (MTR) on the agricultural sector in Schleswig-Holstein, a federal state in Germany. First, a very detailed farm group linear programming model is built to quantify the effects on agricultural ...
Henning, Christian H.C.A., Henningsen, Arne, Müller-Scheeßel, Jörg, Struve, Carsten   +3 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Impact of Globalization and Liberalization on Growth, Employment and Poverty: A Case Study of Pakistan [PDF]

Globalization, Liberalization, Economic growth, Employment, Poverty, Structural adjustment ...
Anwar, Tilat
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

An overview of education: the management of public education [PDF]

Revista Electrónica Interuniversitaria de Formación del Profesorado, 2010
The article reviews the state of education in Spain and the most relevant trends arising from the current adjustment policies and neoliberal tendencies, which call into question the very existence of the public school system.
Beatriz Quirós Madariaga
doaj  

Structural adjustment and forest resources - the impact of World Bank operations [PDF]

Over two decades, the World Bank has undertaken many structural adjustment operations withgovernments of developing countries. During negotiations for structural adjustment loans (SALs), partner governments agree to specific policy reforms, whose ...
Pandey, Kiran D., Wheeler, David
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Structural Adjustment and Sociocentrism: The Discourse of Governance

Revista Administración Pública y Sociedad, 2016
The paper presents a series of visions, strategies and instruments approach that gained momentum in the mid-90s, from social decay and economic volatility that led to structural adjustment policies.The new visions dyeing the centrality of the individual ...
Horacio Cao, Maximiliano Rey, Arturo Laguado Duca   +2 more
doaj  

The impact of farmland readjustment and consolidation on structural adjustment: The case of Niigata, Japan [PDF]

Improving agricultural productivity is a pressing challenge for rapidly growing economies. Farmland concentration among core famers is instrumental for reaping the economies of scale.
Arimoto, Yutaka
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source