Results 131 to 140 of about 965,004 (336)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Structural Adjustment, Labour and the Poor in Pakistan

open access: yesLahore Journal of Economics
In this paper we cite evidence regarding the likely impact of IMF/World Bank policies on labour and the poor in Pakistan. Our findings show that since the 1987 bout of structural adjustment, public sector employment has decreased while wages have been ...
Shahrukh Rafi Khan, Safiya Aftab
doaj  

The macroeconomic underpinnings of adjustment lending [PDF]

open access: yes
Drawing on conditionality and implementation information for 184 World Bank adjustment loans to 62 countries during the 1980s, the authors examine the macroeconomic underpinnings of Bank supported adjustment programs.
Jaspersen, Fred, Shariff, Karim
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Euler-Equation Estimation for Discrete Choice Models: A Capital Accumulation Application [PDF]

open access: yes
This paper studies capital adjustment at the establishment level. Our goal is to characterize capital adjustment costs, which are important for understanding both the dynamics of aggregate investment and the impact of various policies on capital ...
John Haltiwanger   +2 more
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Gender and Structural Adjustment in Pakistan

open access: yesLahore Journal of Economics
We review the change in the socio-economic condition of women during the intensive period of structural adjustment (1987/88 onwards) in their role as producers, as home managers and as mothers.
Shahrukh Rafi Khan, Mehnaz Ahmad
doaj  

On the Nature of Capital Adjustment Costs [PDF]

open access: yes
This paper studies the nature of capital adjustment at the plant-level. We use an indirect inference procedure to estimate the structural parameters of a rich specification of capital adjustment costs.
John C. Haltiwanger, Russell W. Cooper
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

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