Results 11 to 20 of about 69,991 (228)

Using Molecular Initiating Events to Develop a Structural Alert Based Screening Workflow for Nuclear Receptor Ligands Associated with Hepatic Steatosis [PDF]

, 2016
In silico models are essential to the development of integrated alternative methods to identify organ level toxicity and lead towards the replacement of animal testing.
Cronin, Mark, Mellor, Claire, Steinmetz, Fabian   +2 more
core   +2 more sources

Virtual Extensive Read-Across: A New Open-Access Software for Chemical Read-Across and Its Application to the Carcinogenicity Assessment of Botanicals

Molecules, 2022
Read-across applies the principle of similarity to identify the most similar substances to represent a given target substance in data-poor situations. However, differences between the target and the source substances exist.
Edoardo Luca Viganò, Erika Colombo, Giuseppa Raitano, Alberto Manganaro, Alessio Sommovigo, Jean Lou CM Dorne, Emilio Benfenati   +6 more
doaj   +1 more source

Identifying chemicals based on receptor binding/bioactivation/mechanistic explanation associated with potential to elicit hepatotoxicity and to support structure activity relationship-based read-across

Current Research in Toxicology, 2023
The liver is the most common target organ in toxicology studies. The development of chemical structural alerts for identifying hepatotoxicity will play an important role in in silico model prediction and help strengthen the identification of analogs used
Shengde Wu, George Daston, Jane Rose, Karen Blackburn, Joan Fisher, Allison Reis, Bastian Selman, Jorge Naciff   +7 more
doaj   +1 more source

Worldwide food recall patterns over an eleven month period: A country perspective. [PDF]

, 2008
Background Following the World Health Organization Forum in November 2007, the Beijing Declaration recognized the importance of food safety along with the rights of all individuals to a safe and adequate diet.
A Ma'ayan, Andrea Petróczi, B Halkier, Declan P Naughton, DJ Watts, E Millstone, EJ Kok, F Bergeaud-Blackler, G Csárdi, GA Kleter, HJP Marvin, JC Nacher, K Birchard, M Hugas, M Latapy, MC Palumbo, MEJ Newman, MEJ Newman, MEJ Newman, P Coppens, P Paulsen, R Development Core Team, R Kleemann, SB Seidman, SR Prolx, T Sergent, Tamás Nepusz   +26 more
core   +3 more sources

XML Schema-based Minification for Communication of Security Information and Event Management (SIEM) Systems in Cloud Environments [PDF]

, 2014
XML-based communication governs most of today's systems communication, due to its capability of representing complex structural and hierarchical data.
El-Khouly, Mahmoud, Mostafa, Mahmoud, Moussa, Bishoy   +2 more
core   +3 more sources

In Silico Prediction of Chemical Toxicity for Drug Design Using Machine Learning Methods and Structural Alerts

Frontiers in Chemistry, 2018
During drug development, safety is always the most important issue, including a variety of toxicities and adverse drug effects, which should be evaluated in preclinical and clinical trial phases.
Hongbin Yang, Lixia Sun, Weihua Li, Guixia Liu, Yun Tang   +4 more
doaj   +1 more source

Open-source digital technologies for low-cost monitoring of historical constructions [PDF]

, 2017
This paper shows new possibilities of using novel, open-source, low-cost platforms for the structural health monitoring of heritage structures. The objective of the study is to present an assessment of increasingly available open-source digital modeling ...
Basto, Camilo, Chacón Flores, Rolando Antonio, Pelà, Luca   +2 more
core   +2 more sources

Modeling and insights into the structural characteristics of drug-induced autoimmune diseases

Frontiers in Immunology, 2022
The incidence and complexity of drug-induced autoimmune diseases (DIAD) have been on the rise in recent years, which may lead to serious or fatal consequences. Besides, many environmental and industrial chemicals can also cause DIAD.
Huizhu Guo, Peitao Zhang, Ruiqiu Zhang, Yuqing Hua, Pei Zhang, Xueyan Cui, Xin Huang, Xiao Li, Xiao Li   +8 more
doaj   +1 more source

Security in networks of unmanned aerial vehicles for surveillance with an agent-based approach inspired by the principles of blockchain [PDF]

, 2019
Unmanned aerial vehicles (UAVs) can support surveillance even in areas without network infrastructure. However, UAV networks raise security challenges because of its dynamic topology.
García-Magariño, I., Lacuesta, R., Lloret, J., Rajarajan, M.   +3 more
core   +2 more sources

Bedside check of medication appropriateness (BED-CMA) as a risk-based tool for bedside clinical pharmacy services: A proof-of-concept study at the trauma surgery ward

Computational and Structural Biotechnology Journal, 2023
Background: Bedside clinical pharmacy prevents drug-related problems, but is not feasible in many countries due to limited resources. Hence, clinical rules using structural information in the electronic health record can help identifying potentially ...
Greet Van De Sijpe, Wencke Hublou, Peter Declercq, Willem-Jan Metsemakers, An Sermon, Minne Casteels, Veerle Foulon, Charlotte Quintens, Isabel Spriet   +8 more
doaj   +1 more source