Results 121 to 130 of about 3,177,476 (315)

Glacios 2 Cryo-TEM and Smart EPU Software streamline Cryo-EM for drug design with higher throughput [PDF]

BIO Web of Conferences
Koh Adrian, Adams Michael, Yu Lingbo, Grollios Fanis, van Knippenberg Bart, Kotecha Abhay, Greber Basil, Raschdorf Oliver, Ortiz Julio, Pryor Edward, Lengyel Jeffrey   +10 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Thermo Scientific Smart EPU Software: Towards autonomous screening [PDF]

BIO Web of Conferences
Grollios Fanis, Kohr Holger, Ortiz Julio, Pryor Edward   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The structural substrate of brain function: analysis of brain structural networks based on diffusion-weighted imaging

, 2014
The brain is a complex neural network with a hierarchical organization and the mapping of its elements and connections is an important step towards the understanding of its function.
Andreotti, Jennifer
core  

Perturbation Analysis for Robust Damage Detection with Application to Multifunctional Aircraft Structures [PDF]

, 2014
The most widely known form of multifunctional aircraft structure is smart structures for structural health monitoring (SHM). The aim is to provide automated systems whose purposes are to identify and to characterize possible damage within structures by ...
HAJRYA, Rafik, MECHBAL, Nazih
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Machine learning and data-driven methods for steel constitutive modeling: a state-of-the-art review and validation

Discover Civil Engineering
In this work we develop and validate neural-network (NN) constitutive models for structural steels under monotonic and cyclic loading, using internal-variable inputs to encode path dependence. For monotonic tension at $$200-800^{\circ }C$$ (Kirby-Preston
Stefanos Voulgaris, Spyros Chandrinos, Ilias Chamatidis, Giorgos Kazakis, Pantelis Tsakalis, Chara Ch. Mitropoulou, Stelios K. Georgantzinos, Denis Istrati, Nikos D. Lagaros   +8 more
doaj   +1 more source

Experimental Analysis of Hybrid Panels Combining Flax/PLA Composite with UHMWPE and Steel Under Ballistic Impact

Journal of Natural Fibers
This study investigates the feasibility of substituting UHMWPE and steel with flax/PLA green composite in ballistic applications with the objective to increase sustainability and cost-effectiveness.
Liu Jiao-Wang, Samuel Charca, Borja Valverde, J.A. Loya, Carlos Santiuste   +4 more
doaj   +1 more source

Modal identification of the San Francesco church in Pisa, Italy

, 2020
The preservation of Cultural Heritage assets from natural and man-made disasters is of great importance for communities because of their architectural and social value.
Canessa Francesca, Emanuele Lorenzo, Elena Savelli, Chellini Giuseppe, Carlo Resta, De falco Anna, Giacomo Sevieri   +6 more
core