Results 111 to 120 of about 6,922,711 (307)

Metamodel-based importance sampling for structural reliability analysis

, 2011
Structural reliability methods aim at computing the probability of failure of systems with respect to some prescribed performance functions. In modern engineering such functions usually resort to running an expensive-to-evaluate computational model (e.g.
Deheeger, F., Dubourg, V., Sudret, B.
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Structural weight analysis of hypersonic aircraft [PDF]

The weights of major structural components of hypersonic, liquid hydrogen fueled aircraft are estimated and discussed. The major components are the body structure, body thermal protection system tankage and wing structure.
Ardema, M. D.
core   +1 more source

Glacios 2 Cryo-TEM and Smart EPU Software streamline Cryo-EM for drug design with higher throughput [PDF]

BIO Web of Conferences
Koh Adrian, Adams Michael, Yu Lingbo, Grollios Fanis, van Knippenberg Bart, Kotecha Abhay, Greber Basil, Raschdorf Oliver, Ortiz Julio, Pryor Edward, Lengyel Jeffrey   +10 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Probabilistic structural analysis by extremum methods [PDF]

The objective is to demonstrate discrete extremum methods of structural analysis as a tool for structural system reliability evaluation. Specifically, linear and multiobjective linear programming models for analysis of rigid plastic frames under ...
Nafday, Avinash M.
core   +1 more source

Thermo Scientific Smart EPU Software: Towards autonomous screening [PDF]

BIO Web of Conferences
Grollios Fanis, Kohr Holger, Ortiz Julio, Pryor Edward   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Structural analysis of silicon solar arrays [PDF]

Engineering mechanics in structural design of silicon solar ...
Butterworth, L. W., Yasui, R. K.
core   +1 more source

Machine learning and data-driven methods for steel constitutive modeling: a state-of-the-art review and validation

Discover Civil Engineering
In this work we develop and validate neural-network (NN) constitutive models for structural steels under monotonic and cyclic loading, using internal-variable inputs to encode path dependence. For monotonic tension at $$200-800^{\circ }C$$ (Kirby-Preston
Stefanos Voulgaris, Spyros Chandrinos, Ilias Chamatidis, Giorgos Kazakis, Pantelis Tsakalis, Chara Ch. Mitropoulou, Stelios K. Georgantzinos, Denis Istrati, Nikos D. Lagaros   +8 more
doaj   +1 more source