Results 91 to 100 of about 3,177,476 (315)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Scientific ReportsThe paper presents a two-level metametrial homogenization procedure, in which the mechanical behavior of a bar with non-uniform stiffness profile is considered. The connection between the microstructure (spring-mass model) and the surrogate model (simple
Krzysztof Szajek, Wojciech Sumelka
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Influence of structural nonlinearities in stall-induced aeroelastic response of pitching airfoils
, 2014 Stall-induced vibrations are a relevant aeroelastic problem for very flexible aero-structures. Helicopter blades, wind turbines, or other rotating components are severely inflicted to vibrate in stall condition during each revolution of its rotor ...
Pereira, Daniel A. +2 more
core +2 more sources
Investigation of raw timber elements for the design of a hunting stand structure [PDF]
E3S Web of ConferencesThere is an increasing need for less resource-intensive and waste-reducing measures in the design and production of timber structures. Traditionally, irregular branches from tree crowns are often left unused, despite making up nearly 50% of a tree's ...
Bergadewata Gerdan +2 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
Survey of Finite Element Method-Based Real-Time Simulations
Applied Sciences, 2019 The finite element method (FEM) has deservedly gained the reputation of the most powerful, highly efficient, and versatile numerical method in the field of structural analysis.
Dragan Marinkovic, Manfred Zehn
doaj +1 more source