Results 91 to 100 of about 26,806,177 (307)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 1918 Mode of access: Internet.Environ Dsgn TH1.A6: v.1: Gift of John Galen Howard"A revised reprint from the 12 issues for 1917 of the Journal of the American Institute of Architects, Structural Service Department.
American Institute of Architects. Structural Service Dept.
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
DAMAGE ANALYSIS OF STEEL-CONCRETE COMPOSITE BEAMS UNDER STATIC LOADS
, 2020 This paper presents a study of the static behavior of steel-concrete composite beams with different types of damage. Since the behavior of a composite beam under load is governed by the shear connection, it is important to investigate the overall ...
Xinqun Zhu +5 more
core +1 more source
Survey of Finite Element Method-Based Real-Time Simulations
Applied Sciences, 2019 The finite element method (FEM) has deservedly gained the reputation of the most powerful, highly efficient, and versatile numerical method in the field of structural analysis.
Dragan Marinkovic, Manfred Zehn
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Advanced Intelligent SystemsClusters, an aggregation of several to thousands of atoms, molecules, or ions, are the building blocks of novel functional materials by atomic manufacturing and exhibit excellent applications in catalysis, quantum information, and nanomedicine.
Junfeng Gao +7 more
doaj +1 more source
Influence of Failure Strain of Different Aluminium Alloys on Dynamic Problems
Engineering Transactions, 2014 In this work an experimental-numerical methodology is devised for analyzing ductile fracture of two aluminum alloys under different values of stress triaxiality (0.2 ≤ η ≤ 1.2) and Lode parameter (−1 ≤ μ ≤ 0).
Marcos RODRIGUEZ-MILL´AN +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source