Results 81 to 90 of about 26,806,177 (307)
A new method for ship inner shell optimization based on parametric technique
International Journal of Naval Architecture and Ocean Engineering, 2015 A new method for ship Inner Shell optimization, which is called Parametric Inner Shell Optimization Method (PISOM), is presented in this paper in order to improve both hull performance and design efficiency of transport ship.
Yan-Yun Yu, Yan Lin, Ming Chen, Kai Li
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Understanding the first steps of the complement classical pathway: Structural studies on C1-antibody complexes [PDF]
, 2018 The complement system is a complex network of plasma and membrane-associated proteins, which can produce effective immune responses to infectious micro-organisms. Deficiencies of complement proteins cause diseases like systemic lupus erythematosus (SLE),
Sub Crystal and Structural Chemistry +2 more
core
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Different analysis strategies in the structural assessment of the St. Anne of Pietra Perduca oratory
, 2014 The paper deals with some open issues about direct investigations and structural analysis related to the conservation of the architectural heritage. At first, it discusses the theme of the importance of the direct investigation on the monument, aimed to ...
BESANA, DANIELA +2 more
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Scientific ReportsThe paper presents a two-level metametrial homogenization procedure, in which the mechanical behavior of a bar with non-uniform stiffness profile is considered. The connection between the microstructure (spring-mass model) and the surrogate model (simple
Krzysztof Szajek, Wojciech Sumelka
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Role of structural analysis in floodway design process
, 2019 Floodways are road infrastructure designed to be overtopped during flood events of relatively low average recurrence interval. When the floodwater recedes, floodways are expected to be fully functional.
Lokuge, Weena +3 more
core +1 more source
Investigation of raw timber elements for the design of a hunting stand structure [PDF]
E3S Web of ConferencesThere is an increasing need for less resource-intensive and waste-reducing measures in the design and production of timber structures. Traditionally, irregular branches from tree crowns are often left unused, despite making up nearly 50% of a tree's ...
Bergadewata Gerdan +2 more
doaj +1 more source