Results 61 to 70 of about 6,922,711 (307)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Molecular simulation analysis of structural variations in lipoplexes

, 2011
We use a coarse-grained molecular model to study the self-assembly process of complexes of cationic and neutral lipids with DNA molecules ("lipoplexes") - a promising nonviral carrier of DNA for gene therapy.
Farago, Oded, Grønbech-Jensen, Niels
core   +1 more source

Design of FRP reinforced concrete beams for serviceability requirements

Journal of Civil Engineering and Management, 2012
Serviceability Limit States (SLS) may govern the design of concrete elements internally reinforced with Fibre Reinforced Polymer (FRP) bars because of the mechanical properties of FRP materials.
Cristina Barris, Lluís Torres, Cristina Miàs, Irene Vilanova   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Implementation of elastic-plastic structural analysis into NASTRAN [PDF]

, 1983
Elastic-plastic analytic capabilities were incorporated into the NASTRAN program. The present implementation includes a general rigid format and additional bulk data cards as well as to two new modules. The modules are specialized to include only perfect
Levy, A., Ogilvie, P. L., Pifko, A. B.
core   +1 more source

Deep learning-based system for automated damage detection and quantification in concrete pavement

Results in Engineering
The increasing volume of vehicle traffic and climate change significantly impact the performance of road infrastructure, necessitating comprehensive analyses throughout the road lifecycle to ensure its resilience.
Hellen Garita-Durán, Julien Philipp Stöcker, Michael Kaliske   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

An Analysis of Tournament Structure

CoRR, 2016
This paper explores a novel way for analyzing the tournament structures to find a best suitable one for the tournament under consideration. It concerns about three aspects such as tournament conducting cost, competitiveness development and ranking precision. It then proposes a new method using progress tree to detect potential throwaway matches.
Nhien Pham Hoang Bao, Hiroyuki Iida
openaire   +2 more sources