Results 61 to 70 of about 3,177,476 (315)

Role of structural analysis in floodway design process

, 2019
Floodways are road infrastructure designed to be overtopped during flood events of relatively low average recurrence interval. When the floodwater recedes, floodways are expected to be fully functional.
Lokuge, Weena, Etemadi, Elahe, Karunasena, Warna, Greene, Isaac   +3 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Private analysis of graph structure [PDF]

Proceedings of the VLDB Endowment, 2011
We present efficient algorithms for releasing useful statistics about graph data while providing rigorous privacy guarantees. Our algorithms work on data sets that consist of relationships between individuals, such as social ties or email communication.
Vishesh Karwa, Sofya Raskhodnikova, Adam D. Smith 0001, Grigory Yaroslavtsev   +3 more
openaire   +1 more source

Design of FRP reinforced concrete beams for serviceability requirements

Journal of Civil Engineering and Management, 2012
Serviceability Limit States (SLS) may govern the design of concrete elements internally reinforced with Fibre Reinforced Polymer (FRP) bars because of the mechanical properties of FRP materials.
Cristina Barris, Lluís Torres, Cristina Miàs, Irene Vilanova   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

DAMAGE ANALYSIS OF STEEL-CONCRETE COMPOSITE BEAMS UNDER STATIC LOADS

, 2020
This paper presents a study of the static behavior of steel-concrete composite beams with different types of damage. Since the behavior of a composite beam under load is governed by the shear connection, it is important to investigate the overall ...
Xinqun Zhu, Faraz Sadeghi, Li, Jianchun, Sadeghi, Faraz (R20539), Zhu, Xinqun, Jianchun Li   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Deep learning-based system for automated damage detection and quantification in concrete pavement

Results in Engineering
The increasing volume of vehicle traffic and climate change significantly impact the performance of road infrastructure, necessitating comprehensive analyses throughout the road lifecycle to ensure its resilience.
Hellen Garita-Durán, Julien Philipp Stöcker, Michael Kaliske   +2 more
doaj   +1 more source

Structural Changes of Yellow Cameleon Domains Observed by Quantitative FRET Analysis and Polarized Fluorescence Correlation Spectroscopy

, 2008
Förster resonance energy transfer (FRET) is a widely used method for monitoring interactions between or within biological macromolecules conjugated with suitable donor-acceptor pairs.
Laptenok, S., Visser, N.V., Kalinin, S., Hornen, H., Hoek, A., van, Kühnemuth, R., Borst, J.W., van Hoek, A., Westphal, A.H., Aker, J., Aker, J.C.M., Kyhnemuth, R., Laptenok, S.P., Seidel, C.A.M., Visser, A.J.W.G.   +14 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source