Results 161 to 170 of about 26,806,177 (307)

Special Issue "Molecular Dynamics Simulations and Structural Analysis of Protein Domains (2nd Edition)". [PDF]

Int J Mol Sci
de Brevern AG.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Structural analysis: In theory and practice

, 2009
xi, 617 hlm. : ilus. ; tab.
WILLIAMS,ALAN
core  

Genomic and structural analysis of dacB variants associated with cephalosporin resistance in Pseudomonas aeruginosa. [PDF]

Sci Rep
Mathpal S, Karthik M, Joshi T, Ramesh V, Walia K, Gunasekaran K, Veeraraghavan B, Ramaiah S, Anbarasu A.   +8 more
europepmc   +1 more source

The Analysis of Hybrid Trie Structures.

, 1997
This paper provides a detailed analysis of various implementations of digital tries, including the "ternary search tries" of Bentley and Sedgewick. The methods employed combine symbolic uses of generating functions, Poisson models, and Mellin transforms.
Clément, Julien, Flajolet, Philippe, Vallée, Brigitte   +2 more
openaire   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Structural analysis of rhodopsin states in megabody complexes. [PDF]

Proc Natl Acad Sci U S A
Salom D, Suder DS, Huang W, Wu A, Pardon E, Steyaert J, Kiser PD, Taylor DJ, Gonen S, Palczewski K.   +9 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Structural analysis of bacterial metallothioneins involved in heavy metal detoxification. [PDF]

Bioinformation
Ghosh D, Kumari M, Kumari K, Biswas B, Lenka P, Ghosh S.   +5 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source