Results 181 to 190 of about 26,806,177 (307)

Structural Analysis of Tilvestamab in Complex with AXL. [PDF]

ACS Omega
Christakou E, Lopez AJ, Muruganandam G, Micklem D, Lorens JB, Kursula P.   +5 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Integrative structural analysis of human endosomal NHE6 reveals a lipid-associated gate and disordered C-terminus. [PDF]

Nat Commun
Feilen LP, Sach LK, Tranchant EE, Lalic MR, Havelund JF, Jeria Cerda CM, Ginsthofer M, Ostendorf J, Ma L, Morrow EM, Færgeman NJ, Pedersen SF, Kragelund BB, Autzen HE.   +13 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Internalized stigma, not disability, drives quality-of-life loss in leprosy: A structural analysis. [PDF]

J Eur Acad Dermatol Venereol
Morgaonkar M, Manoj R, Singh S, Deokar S, Gupta A, Kumari P, Agarwal A, Singh M, Gupta A.   +8 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Inclusive design for structural engineers

This multi-authored volume provides guidance on how structural engineers can make positive contributions to inclusive design throughout the built ...
Catterall, Pippa
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Synthesis, structural analysis and reactivity of alkynyl sulfide anions.

Inorg Chem Front
Mondal S, Le Dé Q, Santos Oliveira DA, Rodrigues Silva D, De Feudis A, Bickelhaupt FM, Gessner VH.   +6 more
europepmc   +1 more source

Student perceptions of artificial intelligence in higher education: a structural analysis at an Italian university. [PDF]

Front Psychol
Cammà C, Amenta L, Battaglia S, Celsa C, Cirrincione G, Contino S, Corso PP, Di Dio S, Di Maria G, Enea M, Fagiolini A, Ferraro A, Giuffrè M, Lo Bosco G, Matranga D, Pirrone R, Raimondi FM, Tinnirello I, Uccello R, Vaccaro M, Ventimiglia C, Vitabile S, Midiri M.   +22 more
europepmc   +1 more source