Results 171 to 180 of about 6,922,711 (307)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Structural analysis of OCT4 binding to human LIN28B nucleosomes. [PDF]

Sci Rep
Sinha KK, Halic M.
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

In Silico Functional and Structural Analysis of STAT4 Variants of Uncertain Significance. [PDF]

Genes (Basel)
Bravo-Villagra KM, Maciel-Cruz EJ, Martínez-Contreras RM, Gutiérrez-Hurtado IA, Vizcaíno-Quirarte AM, Muñoz-Valle JF, López-Quintero A.   +6 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A large-scale evolutionary and structural analysis of CLC channels and transporters. [PDF]

Protein Sci
Mishra A, Díaz Vázquez G, Robertson JL.   +2 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Rheological and Structural Analysis of Hyaluronic Acid Fillers Used for Chin Augmentation. [PDF]

Dermatol Ther (Heidelb)
Carbone AC, Neves MLBB, Zinco AG, Nayak VV, de Sousa Mendes LA, De Marchi El Assad A, Câmara-Souza MB, Teixeira S, Machado Filho DA, Murakami FS, De la Torre Canales G.   +10 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Retraction of "Tuning the Magnetic Behavior of Zinc Ferrite via Cobalt Substitution: A Structural Analysis". [PDF]

ACS Omega
Hussain M, Mehmood A, Ali F, Sandhu ZA, Raza MA, Sajid S, Sohaib M, Khan MT, Bhalli AH, Hussain A, Arshid MS, Mehboob N, Al-Sehemi AG.   +12 more
europepmc   +1 more source