Results 101 to 110 of about 5,441,128 (292)

Functional and structural connectome-based predictive modelling of balance in elderly adults

Scientific Reports
Balance control is fundamental to the quality of life among older adults, yet its neural underpinnings remain only partially understood. Despite advances in neuroimaging techniques, the neural correlates of balance are often examined at a regional level ...
Xinyu Liu, Selin Scherrer, Sven Egger, Benedikt Lauber, Wolfgang Taube, Lijing Xin   +5 more
doaj   +1 more source

STRUCTURAL ANALYSIS OF THE SAKHA REPUBLIC (YAKUTIA) FUEL AND ENERGY BALANCE

Известия высших учебных заведений: Проблемы энергетики, 2019
Structure analysis of the dynamics of fuel energy resources production, export and consumption in the Sakha Republic (Yakutia) for the period from 2006 to 2015 has been conducted based on the compiled annual fuel and energy balances, trends in energy ...
N. V. Pavlov, A. E. Ivanova, T. N. Petrova   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Re-modeling the Romanian Fiscal Policy under the Terms of the Economic Crisis [PDF]

Theoretical and Applied Economics, 2011
This paper brings arguments for the necessity to re-think the modality to analize and interpret the Romanian fiscal policy, under the terms of the future adheration to the Euro Zone.
Aura Gabriela SOCOL, Dorin MĂNTESCU
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Insight into Draft Doctoral Paper "Methodological Problems of Calculation of the Structural Budget Balance"

An abstract with insight into problems discussed in doctoral paper "Methodological problems of calculation of the structural budget ...
Kekļa, Jūlija
core  

Knowledge dynamics and structural balance in sociotechnical transitions: A signed network perspective for sustainable integration of emerging technologies

Digital Business
In the context of accelerating digital innovation and environmental transformation, the relationships between emerging technologies, sustainable systems, and public governance are often characterized by intricate patterns of cooperation and conflict ...
Maryam Nooraei Abadeh
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source