Results 161 to 170 of about 1,929,146 (335)

Genesis lunar outpost: An evolutionary lunar habitat [PDF]

Students at the University of Wisconsin-Milwaukee Department of Agriculture undertook a series of studies of lunar habitats during the 1989 to 1990 academic year.
Baschiera, Dino, Fieber, Joe, Moore, Gary T., Moths, Janis   +3 more
core   +1 more source

A comprehensive dataset of protein-protein interactions and ligand binding pockets for advancing drug discovery

Scientific Data
This dataset represents a collection of pocket-centric structural data related to protein-protein interactions (PPIs) and PPI-related ligand binding sites.
Alexandra Moine-Franel, Fabien Mareuil, Michael Nilges, Constantin Bogdan Ciambur, Olivier Sperandio   +4 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia [PDF]

, 2006
Sandra W. Cowan‐Jacob, Gabriele Fendrich, Andreas Floersheimer, Pascal Furet, Janis Liebetanz, Gabriele Rummel, Paul Rheinberger, Mario Centeleghe, Doriano Fabbro, Paul W. Manley   +9 more
openalex   +1 more source

Single-molecule FRET on its way to structural biology in live cells

, 2021
Robert B. Quast, Emmanuel Margeat
openalex   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Statistical inference problems with applications to computational structural biology

, 2017
Parthan Kasarapu
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The changing landscape of membrane protein structural biology through developments in electron microscopy [PDF]

, 2016
Shaun Rawson, Simon P. Davies, Jonathan D. Lippiat, Stephen P. Muench   +3 more
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source