Results 151 to 160 of about 899,634 (266)

The evolving role of structural biology in pharma: integration of X-ray crystallography, cryo-electron microscopy and beyond. [PDF]

Acta Crystallogr D Struct Biol
Chrencik JE, Su HP, Gomez Llorente Y, Palte RL, Klein DJ, Hayes RP, Antine SP, Asmar-Rovira GA, Bertoletti N, Byrne NJ, Carroll BL, Cordeiro CD, Curfman K, Dutko J, Eddins MJ, Fischmann T, Govindarajan B, Hecksel CW, Ho T, Hollenstein K, Hong MR, Hruza A, Ishchenko A, Jaime-Garza M, Jaremko MJ, Knox HL, Kostas J, Krishnamurthy H, Manolaridis I, Noland CL, Partridge AT, Patel SB, Reichert P, Reid JC, Felisberto-Rodrigues C, Shintre CA, Shipman JM, Tamilselvan E, Walker ME, Walker SN, Wang R, Wright KM, Yen TJ, Yoo BK, Gabelli SB.   +44 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

mSphere of Influence: The power of <i>in situ</i>-structural biology without leaving "home". [PDF]

mSphere
Wood NA.
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

From Microscopy to Nanoscopy: Contemporary Physical Methods in Mitochondrial Structural Biology. [PDF]

Int J Mol Sci
Nesterov SV, Rogov AG, Vasilov RG.
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

The 2024 challenges in structural biology summit. [PDF]

Struct Dyn
Nannenga BL, Gonen T.
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Anabolic-Androgenic Steroids Revisited: Structural Biology, Receptor Signaling, and Mechanisms of Anabolic-Androgenic Dissociation. [PDF]

Int J Mol Sci
Wiacek M, Zubrzycki IZ.
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source