Results 171 to 180 of about 893,788 (266)

The transformative impact of AI-enabled AlphaFold 3: evolution, current status, and future prospects in structural biology. [PDF]

Front Artif Intell
Chakraborty C, Bhattacharya M, Lee SS.
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Advantages and Limitations of AlphaFold in Structural Biology: Insights from Recent Studies. [PDF]

Protein J
Li MQC, Wang S, Lin SR, Ting LEN, Wan ZH, Xie G, Zhang J.   +6 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Deep learning-assisted tools to understand the structural biology of the synapse. [PDF]

Biomed Eng Lett
Gáspári Z, Kálmán ZE, Sánta A.
europepmc   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Integrated framework for targeting dynamic penicillin-binding protein 2a via ensemble structural biology and deep generative modeling. [PDF]

Front Microbiol
Pang T, Zhang X, Zhou Y, Yang J.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

An integrative structural biology approach reveals the dynamic organization of the R2SP quaternary chaperone complex. [PDF]

Nat Commun
Santo PE, Chagot ME, Gizardin-Fredon H, Ley M, Chenuel T, Deslignière E, Plassart L, Paiva ACF, Sousa PMF, Bertrand E, Charpentier B, Verheggen C, Quinternet M, Meyer P, Bandeiras TM, Cianférani S, Plisson-Chastang C, Manival X.   +17 more
europepmc   +1 more source