Results 251 to 260 of about 1,929,146 (335)

Structural biology of Nipah virus G and F glycoproteins: Insights into therapeutic and vaccine development. [PDF]

Eur J Microbiol Immunol (Bp)
Salleh MZ.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Deciphering the Structural Biology of GFAP: Connotations of Its Potency in Presaging the Diagnosis for Traumatic Brain Injury and AD. [PDF]

Neurol Int
Kanuri SH, Sirrkay PJ.
europepmc   +1 more source

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

FEBS Open Bio, EarlyView.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey, Lina Riegler‐Berket, Monika Oberer   +2 more
wiley   +1 more source

A structural biology compatible file format for atomic force microscopy. [PDF]

Nat Commun
Jiang Y, Wang Z, Scheuring S.
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

ALS-ENABLE: creating synergy and opportunity at the Advanced Light Source synchrotron structural biology beamlines. [PDF]

J Synchrotron Radiat
Ralston CY, Gupta S, Del Mundo JT, Soe AC, Russell B, Rad B, Tyler J, Paul S, Kahan DN, Kristensen LG, Subramanian S, Kidd S, Burnett K, Sankaran B, Classen S, Prigozhin DM, Taylor JR, Dickert JM, Royal KB, Rozales A, Ortega SL, Allaire M, Nix JC, Hura GL, Holton JM, Hammel M, Adams PD.   +26 more
europepmc   +1 more source

Expression of recombinant glycoproteins in mammalian cells: towards an integrative approach to structural biology

, 2013
A.R. Aricescu, Raymond J. Owens
openalex   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Present and future structural biology activities at DESY and the European XFEL. [PDF]

J Synchrotron Radiat
Oberthür D, Hakanpää J, Chatziefthymiou S, Pompidor G, Bean R, Chapman HN, Weckert E.   +6 more
europepmc   +1 more source