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Mechanisms of Action for Small Molecules Revealed by Structural Biology in Drug Discovery
International Journal of Molecular Sciences, 2020 Small-molecule drugs are organic compounds affecting molecular pathways by targeting important proteins. These compounds have a low molecular weight, making them penetrate cells easily.
Qingxin Li, CongBao Kang
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Structural biology of allergens
Current Allergy and Asthma Reports, 2005Major allergens may have special aerobiological properties and allergenic structures. It would also be instructive to consider the properties of nonallergens and nonallergenic responses. In some cases, nonallergenic responses appear to result from a lack of antigenicity and in others from regulation.
Wayne R, Thomas +2 more
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Current Opinion in Structural Biology, 2010
While we appreciate the complexity of the intracellular environment as a general property of every living organism, we collectively lack the appropriate tools to analyze protein structures in a cellular context. In-cell NMR spectroscopy represents a novel biophysical tool to investigate the conformational and functional characteristics of biomolecules ...
Yutaka, Ito, Philipp, Selenko
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While we appreciate the complexity of the intracellular environment as a general property of every living organism, we collectively lack the appropriate tools to analyze protein structures in a cellular context. In-cell NMR spectroscopy represents a novel biophysical tool to investigate the conformational and functional characteristics of biomolecules ...
Yutaka, Ito, Philipp, Selenko
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Structure and Biology of Cathelicidins
2002Cathelicidins are a recently discovered family of effector molecules in innate immunity. In the past few years, a great deal of investigations have elucidated several aspects of their biology, such as the gene structure and activation mechanism. Despite substantial progress in the field, several issues remain to be clarified, including the biological ...
ZANETTI M. +3 more
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Structure and biology of amylin
Trends in Pharmacological Sciences, 1993Amylin is a recently discovered 37 amino acid peptide secreted into the bloodstream, along with insulin, from pancreatic beta-cells. It is about 50% identical to calcitonin gene-related peptides (CGRP alpha and CGRP beta) and structurally related to the calcitonins.
T J, Rink +3 more
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2009
The neural cell adhesion molecule (NCAM) mediates Ca2+-independent cell-cell and cell-substratum adhesion via homophilic (NCAM-NCAM) and heterophilic (NCAM-non-NCAM molecules) binding. NCAM is highly expressed in the nervous system and plays a key role in neural development, regeneration and synaptic plasticity, including learning and memory ...
Vladislav, Soroka +2 more
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The neural cell adhesion molecule (NCAM) mediates Ca2+-independent cell-cell and cell-substratum adhesion via homophilic (NCAM-NCAM) and heterophilic (NCAM-non-NCAM molecules) binding. NCAM is highly expressed in the nervous system and plays a key role in neural development, regeneration and synaptic plasticity, including learning and memory ...
Vladislav, Soroka +2 more
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Proteasomes: Structure and Biology
Journal of Biochemistry, 1998The proteasome is a multisubunit protease complex with an apparent sedimentation coefficient of 20S. Two types of regulatory complexes, named PA700 and PA28, bind to both ends of the cylindrical 20S proteasome to form the dumbbell-like and football-like proteasomes, respectively.
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Serglycin – Structure and biology
Cellular and Molecular Life Sciences, 2007Serglycin is a proteoglycan found in hematopoietic cells and endothelial cells. It has important functions related to formation of several types of storage granules. In connective tissue mast cells the covalently attached glycosaminoglycan is heparin, whereas mucosal mast cells and activated macrophages contain oversulfated chondroitin sulfate (type E).
S O, Kolset, H, Tveit
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Journal of Biosocial Science, 1983
SummaryAt military recruitment centres in France, data were collected from some 40,000 subjects on their social environment, the amount of education received and occupation, and measurements were taken on height, weight, and performance in tests of mental and physical ability.The secular increase in mean stature is continuing.
G, Olivier, G, Devigne
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SummaryAt military recruitment centres in France, data were collected from some 40,000 subjects on their social environment, the amount of education received and occupation, and measurements were taken on height, weight, and performance in tests of mental and physical ability.The secular increase in mean stature is continuing.
G, Olivier, G, Devigne
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Photonic structures in biology
Nature, 2003Millions of years before we began to manipulate the flow of light using synthetic structures, biological systems were using nanometre-scale architectures to produce striking optical effects. An astonishing variety of natural photonic structures exists: a species of Brittlestar uses photonic elements composed of calcite to collect light, Morpho ...
Pete, Vukusic, J Roy, Sambles
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