Results 1 to 10 of about 2,027,462 (183)

Unusual nonlinear switching in branched carbon nanotube nanocomposites

Scientific Reports, 2023
In this experimental study, we investigate the nonlinear dynamic response of nanocomposite beams composed of polybutylene terephthalate (PBT) and branched carbon nanotubes (bCNTs).
Walter Lacarbonara, Sawan Kumar Guruva, Biagio Carboni, Beate Krause, Andreas Janke, Giovanni Formica, Giulia Lanzara   +6 more
doaj   +1 more source

Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding

Nature Communications, 2023
Hydroxycarboxylic acid receptors (HCA) are expressed in various tissues and immune cells. HCA2 and its agonist are thus important targets for treating inflammatory and metabolic disorders.
Shota Suzuki, Kotaro Tanaka, Kouki Nishikawa, Hiroshi Suzuki, Atsunori Oshima, Yoshinori Fujiyoshi   +5 more
doaj   +1 more source

Epigenetic mechanisms to propagate histone acetylation by p300/CBP

Nature Communications, 2023
Histone acetylation is important for the activation of gene transcription but little is known about its direct read/write mechanisms. Here, we report cryogenic electron microscopy structures in which a p300/CREB-binding protein (CBP) multidomain monomer ...
Masaki Kikuchi, Satoshi Morita, Masatoshi Wakamori, Shin Sato, Tomomi Uchikubo-Kamo, Takehiro Suzuki, Naoshi Dohmae, Mikako Shirouzu, Takashi Umehara   +8 more
doaj   +1 more source

Structural Aspects and Characterization of Structure in the Processing of Titanium Grade4 Different Chips

Metals, 2021
This study presents the structural aspects of the solid-state processing of various titanium chips. The structural characterization of: (1) commercial pure Ti in the as-received state, (2) manufactured chips, and (3) products of the chip processing are ...
Krzysztof Topolski, Jakub Jaroszewicz, Halina Garbacz   +2 more
doaj   +1 more source

Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming

Nature Communications, 2023
M1 macrophages enter a glycolytic state when endogenous nitric oxide (NO) reprograms mitochondrial metabolism by limiting aconitase 2 and pyruvate dehydrogenase (PDH) activity. Here, we provide evidence that NO targets the PDH complex by using lipoate to
Erika M. Palmieri, Ronald Holewinski, Christopher L. McGinity, Ciro L. Pierri, Nunziata Maio, Jonathan M. Weiss, Vincenzo Tragni, Katrina M. Miranda, Tracey A. Rouault, Thorkell Andresson, David A. Wink, Daniel W. McVicar   +11 more
doaj   +1 more source

Structural Modification and Biological Activity of Polysaccharides

Molecules, 2023
Natural polysaccharides are macromolecular substances with a wide range of biological activities. The structural modification of polysaccharides by chemical means can enhance their biological activity.
Ting Zhao, Min Yang, Lina Ma, Xinglong Liu, Qiteng Ding, Guodong Chai, Yang Lu, Hewei Wei, Shuai Zhang, Chuanbo Ding   +9 more
doaj   +1 more source

Intelligent Protein Design and Molecular Characterization Techniques: A Comprehensive Review

Molecules, 2023
In recent years, the widespread application of artificial intelligence algorithms in protein structure, function prediction, and de novo protein design has significantly accelerated the process of intelligent protein design and led to many noteworthy ...
Jingjing Wang, Chang Chen, Ge Yao, Junjie Ding, Liangliang Wang, Hui Jiang   +5 more
doaj   +1 more source

Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10

Nature Communications, 2020
Human ubiquitin E3 ligase E6AP contains a Zn-binding AZUL domain. Here the authors identify and name RAZUL, a domain in proteasome substrate receptor hRpn10 that binds AZUL, recruiting E6AP to proteasomes, and they present the NMR structure of the RAZUL ...
Gwen R. Buel, Xiang Chen, Raj Chari, Maura J. O’Neill, Danielle L. Ebelle, Conor Jenkins, Vinidhra Sridharan, Sergey G. Tarasov, Nadya I. Tarasova, Thorkell Andresson, Kylie J. Walters   +10 more
doaj   +1 more source

Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma

Nature Communications, 2021
Rpn13 is a substrate receptor of the 26S proteasome and an anti-cancer drug target. Here, the authors identify and characterize XL5, a lead compound that binds to the N-terminal Pru domain of human Rpn13 (hRpn13), solve the NMR structure of XL5-ligated ...
Xiuxiu Lu, Venkata R. Sabbasani, Vasty Osei-Amponsa, Christine N. Evans, Julianna C. King, Sergey G. Tarasov, Marzena Dyba, Sudipto Das, King C. Chan, Charles D. Schwieters, Sulbha Choudhari, Caroline Fromont, Yongmei Zhao, Bao Tran, Xiang Chen, Hiroshi Matsuo, Thorkell Andresson, Raj Chari, Rolf E. Swenson, Nadya I. Tarasova, Kylie J. Walters   +20 more
doaj   +1 more source

Characterizing polygonality in biological structures [PDF]

Physical Review E, 2006
Several systems involve spatial arrangements of elements such as molecules or cells, the characterization of which bears important implications to biological and physical investigations. Traditional approaches to quantify spatial order and regularity have relied on nearest neighbor distances or the number of sides of cells.
Costa, Luciano da Fontoura, Rocha, Fernando, de Lima, Silene Araujo   +2 more
openaire   +3 more sources