Results 71 to 80 of about 1,527,783 (278)

Constraints on extended neutral gauge structures [PDF]

Physics Letters B, 1999
Indirect precision data are used to constrain the masses of possible extra Z^prime bosons and their mixings with the ordinary Z. We study a variety of Z^prime bosons as they appear in E_6 and left-right unification models, the sequential Z boson, and the example of an additional U(1) in a concrete model from heterotic string theory.
Erler, Jens, Langacker, Paul
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Empirical validation of ProteinMPNN’s efficiency in enhancing protein fitness

Frontiers in Genetics
Introduction: Protein engineering, which aims to improve the properties and functions of proteins, holds great research significance and application value.
Tianshu Wang, Tianshu Wang, Tianshu Wang, Tianshu Wang, Xiaocheng Jin, Xiaocheng Jin, Xiaocheng Jin, Xiaocheng Jin, Xiaoli Lu, Xiaoping Min, Xiaoping Min, Xiaoping Min, Xiaoping Min, Shengxiang Ge, Shengxiang Ge, Shengxiang Ge, Shengxiang Ge, Shaowei Li, Shaowei Li, Shaowei Li, Shaowei Li   +20 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Conference Report: Teaching Against the Grain: The Challenges of Teaching Qualitative Research in the Health Sciences. A National Workshop on Teaching Qualitative Research in the Health Sciences

Forum: Qualitative Social Research, 2005
This essay reflects on the proceedings of an invitational workshop on the nature and challenges of teaching qualitative research (QR) in health science settings. The context of this workshop is the increasing interest in QR in the health sciences and the
Joan M. Eakin, Eric Mykhalovskiy
doaj  

Curvature constraints from large scale structure [PDF]

Journal of Cosmology and Astroparticle Physics, 2016
We modified the CLASS code in order to include relativistic galaxy number counts in spatially curved geometries; we present the formalism and study the effect of relativistic corrections on spatial curvature. The new version of the code is now publicly available.
Dio E. D., Montanari F., Raccanelli A., Durrer R., Kamionkowski M., Lesgourgues J.   +5 more
openaire   +2 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Airway narrowing and internal structural constraints [PDF]

Journal of Applied Physiology, 2000
A computer model has been developed to simulate the movement restriction in the lamina propria-submucosa (L-S) layer (sandwiched by the basement membrane and the muscle layer) in a cartilage-free airway due to constriction of the smooth muscle layer. It is assumed that the basement membrane is inextensible; therefore, in the two-dimensional simulation,
C Y, Seow, L, Wang, P D, Paré
openaire   +2 more sources

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source