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Structure of the major degradant of ezetimibe
Journal of Pharmaceutical and Biomedical Analysis, 2012In a recent contribution to this Journal Gajjar and Shah described the isolation and structure elucidation of the major alkaline degradant of ezetimibe, a lipid lowering agent [A.K. Gajjar, V.D. Shah, J. Pharm. Biomed. Anal. 55 (2011) 225-229]. Based on (1)H NMR, (13)C NMR and mass spectrometric studies the authors concluded that the structure of the ...
Zsuzsanna, Sánta +4 more
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Nuclease Degradation and the Structure of Ribosomes
European Journal of Biochemistry, 1972Well‐defined patterns of fragments are produced when Escherichia coli ribosomes, both native, dissociated, unfolded, and partially denuded of proteins by treatment with caesium chloride, are digested with pancreatic ribonuclease, and the extracted RNA is fractionated by polyacryl‐amide gel electrophoresis.
J C, Pinder, W B, Gratzer
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Degradation study of irbesartan: Isolation and structural elucidation of novel degradants
Journal of Pharmaceutical and Biomedical Analysis, 2018To assess the stability of Irbesartan under stress conditions, and identify the degradation products, it was subjected to hydrolytic and oxidative stress, according to ICH guideline Q1A (R2). The drug showed degradation only in basic conditions, while it was stable to other stress conditions. Three degradation products were formed, which were separated
V V S R N Anji Karun, Mutha +6 more
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A degradation product of halobetasol propionate—Characterization and structure
Steroids, 2007Degradation of halobetasol propionate was observed in the presence of bases. A single cyclization product was isolated and fully characterized by MS, NMR and X-ray crystallography.
CRAVOTTO G +4 more
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Structural degradation of ceramics
Biomaterials, 1984Fabrication procedures for alumina are summarized and the potential for improving the mechanical strength indicated. Engineering performance of alumina is discussed, particularly in relation to femoral heads, giving emphasis to statistical variations in strength and time dependent strength degradation processes.
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GPC and structural analysis of polyurethane degradation
Polymer Photochemistry, 1986Linear polyurethane (PUR) prepolymers were synthesized starting from diphenylmethane-4, 4'-diisocyanate (MDI) and polyester diol oligomers. Two different types of polyester diols were used: poly(ethylene adipate) (PEA) and poly(ethylene/butylene adipate) (PEBA).
Mencer, Helena Jasna +2 more
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Degradation of Aircraft Structures
2004Maintenance and reliability of aircraft is a major safety concern and economical factor. Many civilian and military aircraft have been in service for 35 years or more. Aircrafts that were originally designed for a service life of 20 years are currently considered for life extensions of up to 80 years.
N. Meyendorf +7 more
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Structural organization of the RNA-degrading exosome
Current Opinion in Structural Biology, 2008The RNA exosome participates in the degradation and processing of a wide range of RNA molecules. Recent advances in understanding how the exosome is organized and functions largely stem from structural studies. Crystal structures of archaeal exosomes bound to RNA and of the corresponding nine-subunit human exosome core show that the archaeal and ...
Lorentzen, E.; id_orcid 0000-0001-6493-7220 +2 more
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FLAP, 2019
Summary: Probabilistic risk and safety analyses are used in virtually all industries to assess whether the risk of operating complex technical systems is low enough to be socially acceptable. As of today, these analyses rely mainly on stochastic Boolean models such as fault trees or reliability block diagrams.
Antoine Rauzy, Liu Yang
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Summary: Probabilistic risk and safety analyses are used in virtually all industries to assess whether the risk of operating complex technical systems is low enough to be socially acceptable. As of today, these analyses rely mainly on stochastic Boolean models such as fault trees or reliability block diagrams.
Antoine Rauzy, Liu Yang
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The Research on Degradation Failure Life and Degradation Data Structure
Advanced Materials Research, 2013In order to solve the reliability assessment in the case of competition failure induced by the coexistence between burst-type failure and degradation-type failure in the product, the method of degradation amount distribution was adopted to describe the degradation process of performance in product.
Yi Dong Wang +3 more
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