Results 51 to 60 of about 2,823,698 (212)
Applications of integrated design/analysis systems in aerospace structural design [PDF]
Integrated structural analysis and design systems and structural optimization procedures are being used in a production environment. Successful use of these systems requires experienced personnel.
Lerner, Edwin +2 more
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Aircraft Conceptual Structural Design Using the AMMIT Structural Analysis Tool [PDF]
Aircraft conceptual structural design is the process of developing and refining an idea for an aircraft into a feasible structural design. The process typically involves multiple evaluations of a single configuration and can require designers to examine ...
Horvath, Bryce L.
core +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Blade design and operating experience on the MOD-OA 200 kW wind turbine at Clayton, New Mexico [PDF]
, 1979 Two 60 foot long aluminum wind turbine blades were operated for over 3000 hours on the MOD-OA wind turbine. The first signs of blade structural damage were observed after 400 hours of operation. Details of the blade design, loads, cost, structural damage,
Linscott, B. S., Shaltens, R. K.
core +1 more source
A Structured Systems Approach for Optimal Actuator-Sensor Placement in Linear Time-Invariant Systems
, 2012 In this paper we address the actuator/sensor allocation problem for linear time invariant (LTI) systems. Given the structure of an autonomous linear dynamical system, the goal is to design the structure of the input matrix (commonly denoted by $B$) such ...
Aguiar, A. Pedro +2 more
core +2 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Design sensitivity analysis with Applicon IFAD using the adjoint variable method [PDF]
A numerical method is presented to implement structural design sensitivity analysis using the versatility and convenience of existing finite element structural analysis program and the theoretical foundation in structural design sensitivity analysis ...
Choi, Kyung K., Frederick, Marjorie C.
core +1 more source
Exploratory study into a safety format for composite columns exposed to fire [PDF]
, 2019 Current performance based structural fire engineering approaches evaluate structural behaviour under prescribed fire scenarios. The mechanical properties of the materials, the load conditions and geometric parameters are all however fraught with ...
Elhami Khorasani, Negar +3 more
core +1 more source