Results 71 to 80 of about 2,823,698 (212)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Optimum structural design with static aeroelastic constraints [PDF]
The static aeroelastic performance characteristics, divergence velocity, control effectiveness and lift effectiveness are considered in obtaining an optimum weight structure. A typical swept wing structure is used with upper and lower skins, spar and rib
Bowman, Keith B +2 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Thermal-structural combined loads design criteria study [PDF]
A study was conducted to determine methodology for combining thermal structural loads and assessing the effects of the combined loads on the design of a thermal protection system and a hot structure of a high cross range delta wing space shuttle orbiter ...
Brogren, E. W. +4 more
core +1 more source
Structural Design Guidelines for Pervious Concrete Pavements [PDF]
, 2019 Pervious pavements have gained popularity in recent years as the transportation industry focuses on sustainability and environmental impact. This research investigated the structural design of pervious concrete pavements.
Smith, April
core +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Arrow-wing supersonic cruise aircraft structural design concepts evaluation. Volume 4: Sections 15 through 21 [PDF]
The analyses performed to provide structural mass estimates for the arrow wing supersonic cruise aircraft are presented. To realize the full potential for structural mass reduction, a spectrum of approaches for the wing and fuselage primary structure ...
Davis, G. W., Sakata, I. F.
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Integration of Design, Thermal, Structural, and Optical Analysis, Including Thermal Animation [PDF]
, 1993 In many industries there has recently been a concerted movement toward 'quality management' and the issue of how to accomplish work more efficiently.
Amundsen, Ruth M.
core +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source