Results 71 to 80 of about 13,517,481 (303)
Travelling Fires for Structural Design [PDF]
, 2011 Traditional methods for specifying thermal inputs for the structural fire analysis of buildings assume uniform burning and homogeneous temperature conditions throughout a compartment, regardless of its size. This is in contrast to the observation that
Stern-Gottfried, Jamie
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Fabrication of Dry Connection Through Stamping and Milling of Green-State Concrete
BuildingsThis study addresses the fabrication challenges associated with producing diverse geometries for concrete dry connections, particularly regarding cost, time, and geometric limitations. The research investigates methods for fabricating precise, rebar-free
Abtin Baghdadi +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Automated generation of structural solutions based on spatial designs
, 2013 To aid in the understanding of design processes and to support the involved actors, a Research Engine (RE) is under development. The RE is a set of automated computational processes that simulate a spatial–structural design process. The first developed
Davila Delgado, J. M. +7 more
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
SensorsIn lightweight design, the usage of different optimised materials is widespread. The interfaces between two different materials are prone to damage and, therefore, the Structural Health Monitoring (SHM) of these areas is of interest. A new method for the
Thomas Wolfsgruber +2 more
doaj +1 more source
Highly efficient semi‐active oil damper with energy recovery system
Japan Architectural Review, 2019 This paper presents a novel semi‐active oil damper developed to overcome the limitations of existing oil dampers by introducing a unique energy recovery system.
Ryusuke Fukuda, Haruhiko Kurino
doaj +1 more source
An Automated Stabilization Method for Spatial-to-Structural Design
, 2011 A spatial-structural design process can be investigated via a so-called research engine, in which a spatial design is transformed into a structural design and vice versa.
Smulders, C.D.J. +3 more
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