Results 81 to 90 of about 13,517,481 (303)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Automated simulation and study of spatial-structural design processes
, 2013 A so-called "Design Process Investigation toolbox" (DPI toolbox), has been developed. It is a set of computational tools that simulate spatial-structural design processes. Its objectives are to study spatial-structural design processes and to support the
Davila Delgado, J.M. +3 more
core
Structural design optimization [PDF]
, 2007 Guest Editorial, Special Issue on Structural Design Optimization, Advances in Structural Engineering, An International Journal, 2007, Vol.
Liang, Qing Quan
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Analysis on characteristics of future aircraft structure design
Hangkong gongcheng jinzhanAircraft has become indispensable tools for modern warfare, convenient transportation, and economic development. With the advancements in technology, aircraft is being assigned increasingly diverse mission requirements, presenting comprehensive ...
LIU Lei, YAO Xionghua, LYU Yi
doaj +1 more source
Optimising building structural topologies
, 2014 A strategy to perform structural optimisation at early stages of the building design process has been developed. It uses a complete building spatial design as input to generate astructural topology.
Papadrakakis, M. +4 more
core
Design as a Catalyst for Sustainability Transitions [PDF]
, 2018 Transitions towards sustainability need for radical and structural changes in the social, cultural and organisational dimensions in addition to technological innovations and infrastructural changes.
Gaziulusoy, Idil, Erdogan Öztekin, Elif
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
, 2008 Het onderzoek bij de leerstoel Constructief Ontwerpen (Algemeen & Integratie) is gericht op de thema's: duurzaamheid, integratie en transparantie. Deze thema's zijn actueel in het moderne bouwen, maatschappelijk relevant en noodzakelijk om te komen ...
Herwijnen, van, F. +1 more
core
Perspective: the gist of public tender for service design [PDF]
, 2018 Governments around the world are increasingly formalising design as an innovative approach to renew public services. In this development, the capabilities of external service design consultancies often play an important part, which calls for new insights
Person, Oscar +3 more
core +1 more source