Results 61 to 70 of about 13,517,481 (303)
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Study on development technology of aircraft smart cockpit
Hangkong gongcheng jinzhanIt is clear that the smart development of the aircraft cockpit is inevitable，and the study on the development technology of aircraft smart cockpit can provide the reference support for future aircraft smart cockpit design.
LIU Guanghui, SUN Di, LI Yuanyuan
doaj +1 more source
On the line structure of designs
Discrete Mathematics, 1991 A \((v,b,r,k,\lambda)\)-design is a pair \((S,\beta)\), where \(S\) is a \(v\)- set, whose elements are called points, and \(\beta\) is a collection of \(b\) \(k\)-subsets of \(S\), called blocks, such that any pair of points is contained in exactly \(\lambda\) blocks. The parameter \(r=\lambda(v-1)/(k- 1)\) denotes the number of blocks through a point.
openaire +3 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Nothing is lost, nothing is created, everything is reused: structural design for a circular economy [PDF]
Structural designers’ efforts to reduce environmental impacts traditionally consist of developing systems that minimise material quantities or use low-impact materials.
Brütting, Jan, Fivet, Corentin
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
A Two-Level Comparative Assessment of Concrete Building Systems and Member Typologies
BuildingsConcrete building systems require decisions at both the member and the building level, because locally efficient cross sections do not necessarily lead to a favorable whole-building response.
Abtin Baghdadi +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
BuildingsDigital fabrication with concrete enables manufacturing of geometrically complex and individualized elements, increasing the need for scalable non-destructive quality-control methods.
Bartłomiej Sawicki +2 more
doaj +1 more source
Introducing Experience Goals into Packaging Design [PDF]
, 2016 Consumer experiences are an increasingly important driving force for commerce, affecting also packaging design. Yet, experience design for packages is rarely studied.
Roto, Virpi +3 more
core +1 more source