Results 131 to 140 of about 8,308,567 (300)
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
, 2018 Understanding basic concepts and assumptions is a crucial step in the learning process of any subject, yet today it is not always achieved. A change of the current teaching method is suggested in this paper through the implementation of new learning ...
Fernandez, Ignasi, +1 more
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BuildingsProto-AGI describes the intermediate stage of artificial intelligence between narrow task-specific tools and fully autonomous general intelligence. This paper presents the first formal operationalisation of Proto-AGI traits within a cross-domain digital ...
Jawed Qureshi +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
, 1987 First National Structural Engineering Conference 1987, Melbourne, 26-28 August 1987 : preprints of ...
Vic.) National Structural Engineering Conference (1st : 1987 : Melbourne, (9884903)
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
The 2010 fib Model Code for Structural Concrete: a new approach to structural engineering
, 2011 The fib Model Code is a recommendation for the design of reinforced and prestressed concrete which is intended to be a guiding document for future codes. Model Codes have been published before, in 1978 and 1990.
Bigaj-van Vliet, A., Walraven, J.C.
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