Results 111 to 120 of about 8,308,567 (300)

A Novel Hybrid Numerical Scheme for Solving Time-Fractional Viscoelastic Models in Structural Engineering: Application to Creep and Relaxation Behavior in Polymer Composites

Fractal and Fractional
This paper proposes a novel hybrid numerical scheme that augments the classical L1 finite-difference approximation of the Caputo fractional derivative of order α∈(0,1] with a selective shifted Grünwald–Letnikov correction (controlled by a shift parameter
Lei Ren, Shixin Jin
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Machine Learning Prediction of Shear Strength in Cold-Formed Steel Modular Construction-Optimised (MCO) Beam

Buildings
The rapid growth of modular construction has increased the demand for accurate and computationally efficient methods for predicting the shear performance of cold-formed steel members.
Drew Thomas Gray, Lenganji Simwanda, Mohamed Sifan, Keerthan Poologanathan, Thushanthan Kannan   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Neuro-Symbolic Framework for Ensuring Deterministic Reliability in AI-Assisted Structural Engineering: The SYNAPSE Architecture

Buildings
This paper addresses the opportunities and risks of integrating Large Language Models (LLMs) into structural engineering. Exclusive reliance on LLMs is inadequate in this field, because their probabilistic nature can lead to hallucinations and ...
Adriano Castagnone, Giuseppe Nitti
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Editorial: Methods and applications in computational methods in structural engineering

Frontiers in Built Environment, 2023
Alejandro Jiménez Rios, Manolis Georgioudakis, Yang Song, Samuel Ruiz-Capel   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Seismic vulnerability of existing buildings: non-invasive approach for dynamic behaviour assessment

GEOmedia, 2018
This paper presents a brief overview of the concept of seismic risk, with particular regard to existing civil buildings. Given that the seismic risk can be expressed as a combination involving seismic hazard and seismic vulnerability, these aspects are ...
Gianluca Acunzo, Michele Vicentino, Antonio Bottaro   +2 more
doaj