Results 91 to 100 of about 855,547 (311)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Shenzhen Daxue xuebao. Ligong banTo investigate the energy dissipation and shock absorption characteristics of expandable polyethylene (EPE) granular soil cushion layers, a 1:10 geometrically scaled indoor test model was constructed for impact testing on EPE granular soil cushions ...
WANG Xing +4 more
doaj +1 more source
The world’s aging infrastructure faces unprecedented challenges. Bridges, the vital lifelines of the transportation network, are in need of innovative solutions to combat the effects of increased traffic loads, environmental stress, and the passage of ...
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Structural Assessment of the Historical Yozgat Clock Tower
Journal of Materials and Engineering Structures, 2022 Many methods and tools have been used to measure time throughout history. People started using mechanical watches instead of sundials and hourglasses because of technological advances.
Burçin Şenol ŞEKER +2 more
doaj
Editorial Board Member - Journal of Architectural Environment & Structural Engineering Research
, 2023 Journal of Architectural Environment & Structural Engineering Research is an open-access, peer-reviewed journal aimed at an international audience. With the rapid growth of the built environment, the physical environment has seen a sharp decline.
FABRIZIO SCOZZESE
core
, 2020 It is becoming an important social problem to make maintenance and rehabilitation of existing short and medium span(10-20 m) bridges because there are a huge amount of short and medium span bridges in service in the world.
Miyamoto, Ayaho +2 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Boosting Ambient Hydrogen Storage in Graphene via Structural and Functional Designs: A Review
Advanced Energy & Sustainability ResearchGraphene with a large specific surface area, excellent mechanical flexibility, and chemical adjustability is a promising medium for reversible hydrogen storage.
Shun Wang, Chaojie Liu, Yongyang Zhu
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source