Results 41 to 50 of about 1,607,586 (321)

Designing by Geometry. Rankine's Theorems of Transformation of Structures. [PDF]

, 2010
William John Macquorn Rankine (1820-1872) was one of the main figures in establishing engineering science in the second half of the 19th. Century. His Manual of Applied Mechanics (1858) gathers most of his contributions to strength of materials and ...
Huerta Fernández, Santiago
core   +1 more source

Base extrusion is found at helical junctions between right- and left-handed forms of DNA and RNA [PDF]

, 2009
Base extrusion is a major structural feature at the junction between B- and Z-DNA (the B–Z junction) where a base pair is broken, and the two bases are extruded from the double helix. Despite the demonstration of base extrusion at the B–Z junction, it is
Kim, Dong Young, Kim, Doyoun, Kim, Kyeong Kyu, Kim, Yang-Gyun, Lee, Sangho, Reddy, Sanjith, Rich, Alexander   +6 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Philosophy of geotechnical design in civil engineering – possibilities and risks [PDF]

Bulletin of the Polish Academy of Sciences: Technical Sciences, 2019
The European standards, developed extensively over last 30 years, are driven by the need for continuous evolution and their Authors’ pursuit of better EU-wide quality in civil engineering – combining safety, economy, and sustainable development.
W. Bogusz, T. Godlewski
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Engine Induced Structural-Borne Noise in a General Aviation Aircraft [PDF]

SAE Technical Paper Series, 1979
<div class="htmlview paragraph">This paper describes a study of engine induced structural-borne noise in a single engine light aircraft. Cabin noise and fuselage vibration levels were recorded during ground tests for engine-attached, engine-detached, interior-installed, and interior-removed configurations.
James F. Unruh, Dennis C. Scheidt
openaire   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Enhancing erosion-corrosion resistance of cupronickel alloys via Al-addition on microstructure and mechanistic

Materials & Design
The influence of Al addition on the synergistic enhancement of erosion-corrosion resistance and mechanical strength of cupronickel alloys was systematically studied.
Yi Yuan, Yizhi Zhao, Wenjing Zhang, Yicheng Cao, Haofeng Xie, Lue Huang, Hao Chu, Hongqian Wang, Dongyan Yue, Xujun Mi   +9 more
doaj   +1 more source

ON THE THREAT OF SUPPLIERS FOR THE ENGINEERING CONSULTING AND DESIGN SERVICES FIRMS [PDF]

Risk in Contemporary Economy, 2014
In the case of companies from engineering consulting and design services industry the classic models of analysis (e.g. Porter's five forces for structural analysis) exhibit interesting aspects in comparison with the situation when applied to traditional ...
Gabriel Sorin STROE
doaj