Results 61 to 70 of about 822,257 (312)

Philosophy of geotechnical design in civil engineering – possibilities and risks [PDF]

Bulletin of the Polish Academy of Sciences: Technical Sciences, 2019
The European standards, developed extensively over last 30 years, are driven by the need for continuous evolution and their Authors’ pursuit of better EU-wide quality in civil engineering – combining safety, economy, and sustainable development.
W. Bogusz, T. Godlewski
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Data-Driven Exploration of Sc-Induced mechanical enhancement in Al-Cu-Li alloys

Materials & Design
A data-driven strategy was developed to identify microalloying elements that simultaneously enhance the yield strength, elongation, and elastic modulus of Al-Cu-Li alloys. Among 71 T6-tempered compositions, Sc was identified as the most promising element
Lyu Jing, Li Yanan, Li Xiwu, Zheng Lei, Li Changlin, Xiao Wei, Wen Kai, Li Ying   +7 more
doaj   +1 more source

Imaging method of seismic advanced detection in tunnels based on ellipse evolving CRP stacking and its application

Yantu gongcheng xuebao, 2018
The seismic advanced detection of tunnels is a common method to estimate faults, karst caves and other adverse geologies, and is an important method to guarantee the safety of tunnel construction.
CHEN Lei 1, LI Shu-cai 1, LIU Bin 1, LI Ming 1, XU Xin-ji 1, LI Ning-bo 2, NIE Li-chao 1
doaj   +1 more source

Rock mass structural surface trace extraction based on transfer learning

Open Geosciences, 2022
To solve engineering geological problems, including water conservancy, transportation, and mining, it is necessary to obtain information on rock mass structures, such as slopes, foundation pits, and tunnels, in time.
Yi Xuefeng, Li Hao, Zhang Rongchun, Gongqiu Zhuoma, He Xiufeng, Liu Lanfa, Sun Yuxuan   +6 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Evaluation of structural and mechanical properties of electrospun nano-micro hybrid of poly hydroxybutyrate-chitosan/silk scaffold for cartilage tissue engineering

Advanced Biomedical Research, 2016
Background: One of the new methods of scaffold fabrication is a nano-micro hybrid structure in which the properties of the scaffold are improved by introducing nanometer and micrometer structures.
Saeed Karbasi, Farnoosh Fekrat, D. Semnani, S. Razavi, Elham Naghash Zargar   +4 more
semanticscholar   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source