Results 61 to 70 of about 347,916 (317)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Model-Based Framework for Real-Time Dynamic Structural Performance Evaluation [PDF]

, 2012
Extreme dynamic events continue to demonstrate the fragility of civil infrastructure worldwide. Over the years, design codes and computational tools have come to reflect an improved understanding of dynamic loads and effects.
Phillips, Brian M., Spencer, Billie F., Jr.   +1 more
core  

Data-Driven Exploration of Sc-Induced mechanical enhancement in Al-Cu-Li alloys

Materials & Design
A data-driven strategy was developed to identify microalloying elements that simultaneously enhance the yield strength, elongation, and elastic modulus of Al-Cu-Li alloys. Among 71 T6-tempered compositions, Sc was identified as the most promising element
Lyu Jing, Li Yanan, Li Xiwu, Zheng Lei, Li Changlin, Xiao Wei, Wen Kai, Li Ying   +7 more
doaj   +1 more source

Imaging method of seismic advanced detection in tunnels based on ellipse evolving CRP stacking and its application

Yantu gongcheng xuebao, 2018
The seismic advanced detection of tunnels is a common method to estimate faults, karst caves and other adverse geologies, and is an important method to guarantee the safety of tunnel construction.
CHEN Lei 1, LI Shu-cai 1, LIU Bin 1, LI Ming 1, XU Xin-ji 1, LI Ning-bo 2, NIE Li-chao 1
doaj   +1 more source

Engine Induced Structural-Borne Noise in a General Aviation Aircraft [PDF]

SAE Technical Paper Series, 1979
<div class="htmlview paragraph">This paper describes a study of engine induced structural-borne noise in a single engine light aircraft. Cabin noise and fuselage vibration levels were recorded during ground tests for engine-attached, engine-detached, interior-installed, and interior-removed configurations.
James F. Unruh, Dennis C. Scheidt
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Structural integrity of engineering components made of functionally graded materials [PDF]

, 2008
Functionally graded materials (FGM) are composite materials with microstructure gradation optimized for the functioning of engineering components. For the case of fibrous composites, the fibre density is varied spatially, leading to variable material ...
Oyekoya, Oyedele O.
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Determination of suitable values for parameters governing B-spline based evolutionary structural optimisation using the boundary element method [PDF]

, 2006
The basic evolutionary structural optimisation concept (ESO) has been developed for several years. Recently, the first ESO algorithm based on the boundary element method (BEM) has been presented.
Wen, Jie
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source