Results 71 to 80 of about 822,257 (312)

Prediction of Scour Depth for Diverse Pier Shapes Utilizing Two-Dimensional Hydraulic Engineering Center’s River Analysis System Sediment Model

Fluids
Examining scouring around bridge piers is crucial for ensuring water-related infrastructure’s long-term safety and stability. Accurate forecasting models are essential for addressing scour, especially in complex water systems where traditional methods ...
Muhanad Al-Jubouri, Richard P. Ray, Ethar H. Abbas   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Advanced Numerical Simulation of Scour around Bridge Piers: Effects of Pier Geometry and Debris on Scour Depth

Journal of Marine Science and Engineering
Investigating different pier shapes and debris Finteractions in scour patterns is vital for understanding the risks to bridge stability. This study investigates the impact of different shapes of pier and debris interactions on scour patterns using ...
Muhanad Al-Jubouri, Richard P. Ray, Ethar H. Abbas   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

COMSOL: Simulation Drives Understanding

CHIMIA, 2022
COMSOL Multiphysics® is a general-purpose simulation software used in all fields of engineering, manufacturing, and scientific research. The software offers fully coupled multiphysics and singlephysics modeling capabilities, simulation data management,
David Spichiger
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Stress Analysis and Stiffness Degradation of Open Cracks Composite Laminates Subjected to External Loads

Biomimetics
Composite laminated structures have extensive applications in the field of bionic engineering. Proficient comprehension of the mechanical properties of these structures is instrumental in the advancement of bionic composite materials.
Zhicheng Huang, Shengyun Su, Xingguo Wang, Fulei Chu   +3 more
doaj   +1 more source

Study on Optimization Design of Reinforced Concrete Special-shaped Column Frame Structure

Chemical Engineering Transactions, 2017
In order to make the design of reinforced concrete (RC) special-shaped column frame structure safe and economical, the optimization design of the structure based on the general design is put forward.
Jingbo An
doaj   +1 more source

Exciton engineering of 2D Ruddlesden–Popper perovskites by synergistically tuning the intra and interlayer structures

Nature Communications
Designing two-dimensional halide perovskites for high-performance optoelectronic applications requires deep understanding of the structure-property relationship that governs their excitonic behaviors. However, a design framework that considers both intra
Songhao Guo, Willa Mihalyi-Koch, Yuhong Mao, Xinyu Li, Kejun Bu, Huilong Hong, Matthew P. Hautzinger, Hui Luo, Dong Wang, Jiazhen Gu, Yifan Zhang, Dongzhou Zhang, Qingyang Hu, Yang Ding, Wenge Yang, Yongping Fu, Song Jin, Xujie Lü   +17 more
semanticscholar   +1 more source