Results 81 to 90 of about 1,624,721 (312)

Improved contact prediction in proteins: Using pseudolikelihoods to infer Potts models

, 2013
Spatially proximate amino acids in a protein tend to coevolve. A protein's three-dimensional (3D) structure hence leaves an echo of correlations in the evolutionary record.
Aurell, Erik, Ekeberg, Magnus, Lan, Yueheng, Lövkvist, Cecilia, Weigt, Martin   +4 more
core   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Advanced Numerical Simulation of Scour around Bridge Piers: Effects of Pier Geometry and Debris on Scour Depth

Journal of Marine Science and Engineering
Investigating different pier shapes and debris Finteractions in scour patterns is vital for understanding the risks to bridge stability. This study investigates the impact of different shapes of pier and debris interactions on scour patterns using ...
Muhanad Al-Jubouri, Richard P. Ray, Ethar H. Abbas   +2 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

COMSOL: Simulation Drives Understanding

CHIMIA, 2022
COMSOL Multiphysics® is a general-purpose simulation software used in all fields of engineering, manufacturing, and scientific research. The software offers fully coupled multiphysics and singlephysics modeling capabilities, simulation data management,
David Spichiger
doaj  

A match coefficient approach for damage imaging in structural components by ultrasonic synthetic aperture focus [PDF]

, 2017
Ultrasonic Synthetic Aperture Focus (SAF) techniques are commonly used to image structural defects. In this paper, a variation of SAF based on ideas borrowed from Matched Field Processing (MFP) is evaluated to reduce artifacts and sidelobes of the ...
Lanza di Scalea, F., Montanini, R, Pau, Annamaria, Quattrocchi, A, Sternini, S   +4 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Study on Optimization Design of Reinforced Concrete Special-shaped Column Frame Structure

Chemical Engineering Transactions, 2017
In order to make the design of reinforced concrete (RC) special-shaped column frame structure safe and economical, the optimization design of the structure based on the general design is put forward.
Jingbo An
doaj   +1 more source

Composite material systems for hydrogen management [PDF]

The task of managing hydrogen entry into elevated temperature structural materials employed in turbomachinery is a critical engineering area for propulsion systems employing hydrogen or decomposable hydrocarbons as fuel. Extant structural materials, such
Pangborn, R. N., Queeney, R. A.
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source