Results 41 to 50 of about 347,916 (317)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
Multi-axial Real-time Hybrid Simulation Framework for Testing Nonlinear Structural Systems with Multiple Boundary Interfaces [PDF]
, 2021 Hybrid simulation is a widely accepted laboratory testing approach that partitions a proposed structure into numerical and physical substructures, for a space- and cost-effective testing method.
Amirali Najafi, Billie F. Spencer, Jr.
core
Materials & DesignThis study presents a semi-supervised learning-guided strategy for designing a dual-stage aging schedule for an Al-Cu-Li alloy, enabling decoupled control of T1 and θ′ precipitates. By integrating active learning and self-training, the approach optimizes
Lyu Jing +11 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Materials & DesignThe influence of Al addition on the synergistic enhancement of erosion-corrosion resistance and mechanical strength of cupronickel alloys was systematically studied.
Yi Yuan +9 more
doaj +1 more source
ON THE THREAT OF SUPPLIERS FOR THE ENGINEERING CONSULTING AND DESIGN SERVICES FIRMS [PDF]
Risk in Contemporary Economy, 2014 In the case of companies from engineering consulting and design services industry the classic models of analysis (e.g. Porter's five forces for structural analysis) exhibit interesting aspects in comparison with the situation when applied to traditional ...
Gabriel Sorin STROE
doaj
New or existing, does it matter?
Acta Polytechnica CTU Proceedings, 2022 Both when designing new and when evaluating existing structures, methods of analysis must be based on established engineering theory and practice. Also, the general principles of structural reliability regarding the treatment of uncertainties when ...
Peter Tanner +2 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source