Results 81 to 90 of about 1,612,198 (310)
Improved contact prediction in proteins: Using pseudolikelihoods to infer Potts models
, 2013 Spatially proximate amino acids in a protein tend to coevolve. A protein's three-dimensional (3D) structure hence leaves an echo of correlations in the evolutionary record.
Aurell, Erik +4 more
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Study on Optimization Design of Reinforced Concrete Special-shaped Column Frame Structure
Chemical Engineering Transactions, 2017 In order to make the design of reinforced concrete (RC) special-shaped column frame structure safe and economical, the optimization design of the structure based on the general design is put forward.
Jingbo An
doaj +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Hydrodynamic Performance of Submerged Plates During Focused Waves
Journal of Marine Science and Engineering, 2019 Submerged horizontal plates are widely employed in research of wave structure interaction as a simplification of coastal and ocean engineering structures.
Qinghe Fang, Can Yang, Anxin Guo
doaj +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
BiomimeticsComposite laminated structures have extensive applications in the field of bionic engineering. Proficient comprehension of the mechanical properties of these structures is instrumental in the advancement of bionic composite materials.
Zhicheng Huang +3 more
doaj +1 more source
Structural optimization by generalized, multilevel decomposition [PDF]
The developments toward a general multilevel optimization capability and results for a three-level structural optimization are described. The method partitions a structure into a number of substructuring levels where each substructure corresponds to a ...
James, B. B. +2 more
core +1 more source
FEBS Open Bio, EarlyView.Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen +6 more
wiley +1 more source
CHIMIA, 2023 COMSOL: Simulation Drives Understanding COMSOL Multiphysics® is a general-purpose simulation software used in all fields of engineering, manufacturing, and scientific research.
David Spichiger
doaj