Results 111 to 120 of about 2,983,469 (361)
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Adaptive Visualisation System for Construction Building Information Models Using Saliency [PDF]
arXiv, 2016 Building Information Modeling (BIM) is a recent construction process based on a 3D model, containing every component related to the building achievement. Architects, structure engineers, method engineers, and others participant to the building process work on this model through the design-to-construction cycle.
arxiv
Building Siting Screening Criteria for Structural Failure Hazards to Occupants [PDF]
, 2019 PresentationEvaluation of occupied buildings for accidental explosion hazards at petrochemical facilities is a vital part of a process safety program and is a key element of facility siting.
Waclawczyk, Johnny, Whitney, Mark
core
Structure as Architecture, Architects as Engineers [PDF]
, 2013 The construction challenges and opportunities demand a new kind of professional, with expertise in structural analysis, architectural design, systems engineering, information technology, and management.
Bidaj, Altin +2 more
core +2 more sources
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Evolution of Persian traditional architecture through the history
Journal of Architecture and Urbanism, 2015 The architecture of Iran is wholly based on the comprehensive use of knowledge of both metaphysical and physical sciences. Architecture and structural engineering in Iran involve a great range of buildings distributed over a vast area from the borders of
Mehrdad Hejazi, Bina Hejazi, Saba Hejazi
doaj +1 more source
A potential tumor suppressor role of PLK2 in glioblastoma
FEBS Open Bio, EarlyView.PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia +5 more
wiley +1 more source
Probabilistic Reliability Assessment of Truss Construction in Matlab Software Platform
Transactions of the VŠB: Technical University of Ostrava, Civil Engineering Series, 2014 This paper deals with the use of probabilistic methods in assessing the reliability of the planar truss support structure. Classical Monte Carlo simulation technique was chosen for calculation of failure probability in structural elements and the entire ...
Vašek Jakub, Krejsa Martin
doaj +1 more source
Probabilistic Performance-Based Hurricane Engineering (PBHE) Framework [PDF]
, 2015 In modern times, hurricanes have caused enormous losses to the communities worldwide both in terms of property damage and loss of life. In light of these losses, a comprehensive methodology is required to improve the quantification of risk and the design
Unnikrishnan, Vipin Unnithan
core +2 more sources
On the General Requirements for Design of Earthquake Resistant Buildings in The Turkish Building Seismic Code of 2018 [PDF]
, 2020 Turkish Building Seismic Code has been revised after eleven years once more and its application is compulsory since the beginning of 2019. The new code is published together with a new Earthquake Hazard Map and it consists of 17 chapters.
Celep, Zekai, Güler, Kadir
core +1 more source