Results 91 to 100 of about 35,892 (312)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Non-Linear Seismic Analysis of Masonry Buildings

, 2010
Non-linear analysis is the most viable tool to get accurate predictions of the actual response of masonry structures under earthquake loading. Analytical methods based on the idealisation of masonry walls with openings as systems of macro-elements allow ...
Parisi, Fulvio
core  

Real-time monitoring to investigate structural performance of hybrid precast concrete educational buildings

, 2019
The motivation and implementation of a real-time structural health monitoring strategy to determine the structural performance of a number of educational buildings recently constructed in Ireland is discussed in this paper.
Hajdukiewicz, Magdalena, Newell, Shane, Goggins, Jamie   +2 more
core   +1 more source

Hysteretic Characteristics of Wood-Frame Structures Under Seismic Motions [PDF]

, 2009
In order to develop seismic codes that can effectively mitigate damage to wood-frame construction under seismic activity, the dynamic characteristics of wood-frame buildings must be well understood.
Sutoyo, Daniel
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Structural Vibration Comfort: A Review of Recent Developments

Buildings
With continuous improvements in the social economy and living standards of individuals, the vibration comfort of building structures has gradually been emphasized by academic and engineering communities, such as vehicle-induced vibrations in buildings ...
Weiping Xie, Yumeng Hua
doaj   +1 more source

Structural and technological solutions for engineering and geological surveys, design and operation of buildings and structures on clay soils [PDF]

BIO Web of Conferences
The paper offers design and technological solutions and recommendations for engineering and geological surveys, as well as the design and operation of buildings and structures on clay soils in Stavropol.
Ovchinnikova Svetlana, Lyamina Alla, Radwan Hussein, Martynyuk Alexey, Konstantinov Ivan, Nikolenko Vladislav   +5 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

FINDING THE STRAIN –STRESS STATE OF ENGINEERING BUILDINGS. OPTIMIZATION OF STRUCTURAL SOLUTIONS

Nauka ta progres transportu, 2010
Industrial pipes are an integral part of the complex structures of enterprises of metallurgical, chemical and other industries from the moment of their advent. Their purpose is to exhaust industrial wastes with residual content of hazardous substances on
V. Ye. Volkova, M. S. Oleynik
doaj  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source