Results 111 to 120 of about 166,491,988 (249)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Effective stiffness of squat structural walls

open access: yes, 2011
Reinforced concrete (RC) structural walls are the primary lateral-load carrying elements in many structures designed to resist earthquakes.
Li, Bing., Xiang, Weizheng.
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

SEI DIscussion Educating Engineers to Create Good-looking Bridges by Paul Gauvreau. Published in Structural Engineering International (SEI) vol. 26(3):198-206

open access: yes, 2017
Payá Zaforteza, IJ. (2017). SEI DIscussion Educating Engineers to Create Good-looking Bridges by Paul Gauvreau. Published in Structural Engineering International (SEI) vol. 26(3):198-206. Structural Engineering International. 27(1):134-135. doi:10.2749/
Paya-Zaforteza, Ignacio   +1 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

A comparative approach to using photogrammetry in the structural analysis of historical buildings

open access: yesAin Shams Engineering Journal
Finite element method (FEM) provides the numerically solving differential equations arising in engineering and mathematical modeling of physical systems. This process begins by determining the assignment of a theoretical node. A node is a single point on
Izzettin Kutlu, Asena Soyluk
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

State-of-the-art review on reducing residential buildings’ risk to tornado hazards

open access: yesFrontiers in Built Environment
Tornadoes represent one of the most formidable natural hazards in the United States. Despite their frequent occurrence, they have received limited yet growing attention in engineering research and practice. Recent updates to the American Society of Civil
Afeez A. Badmus, Elaina J. Sutley
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Load-carrying mechanism to resist progressive collapse of RC buildings

open access: yes, 2014
The slew of high profile engineering calamities in the past decade has demonstrated the disastrous consequence of progressive collapse. However, the low probability of such events actually occurring means it is uneconomical to spend extreme resources to
Qian, Kai, Ma, Jiaxing, Li, Bing
core   +1 more source

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