Results 121 to 130 of about 2,983,469 (361)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

open access: yesFEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal   +3 more
wiley   +1 more source

Sustainable assessment of structures and materials using ground penetrating radar (GPR) [PDF]

open access: yes, 2015
Ground penetrating radar (GPR) is a non-destructive, non-invasive device that can be used to investigate materials in buildings, structures and the ground.
Evans, R
core  

Hierarchical Inspection System Using Visual and MFL Probe Robots [PDF]

open access: yes, 2018
Structural Health Monitoring (SHM) represents a critical appurtenance to modern engineering that amalgamates the skills and techniques from various disciplines of engineering and computational science.
Akbar, Muhammad   +3 more
core   +2 more sources

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei   +7 more
wiley   +1 more source

CFD Simulation of the Interference Effects of Wind Pressures in Building Groups

open access: yesMATEC Web of Conferences, 2018
The effect of interference is a hot topic in structural wind engineering. In order to investigate the phenomena of this effect, some cases, including single interfered building, double interfered buildings and building matrixes, were simulated by the ...
Sun Yi, Wang Mei, Liu Bowei
doaj   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

open access: yesFEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu   +6 more
wiley   +1 more source

Automatic Storage Structure Selection for hybrid Workload [PDF]

open access: yesarXiv, 2020
In the use of database systems, the design of the storage engine and data model directly affects the performance of the database when performing queries. Therefore, the users of the database need to select the storage engine and design data model according to the workload encountered.
arxiv  

Structural optimization of 3D masonry buildings [PDF]

open access: yes, 2012
In the design of buildings, structural analysis is traditionally performed after the aesthetic design has been determined and has little influence on the overall form. In contrast, this paper presents an approach to guide the form towards a shape that is
Attar R.   +9 more
core   +1 more source

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