Results 51 to 60 of about 166,491,988 (249)

Overturning of Non-Structural Components in Low-Moderate Seismicity Regions

Electronic Journal of Structural Engineering, 2008
The objective of this paper is to review key issues concerned with the proper engineering of non-structural components in buildings for their safe and satisfactory performances in projected seismic conditions in regions of low and moderate seismicity ...
Nelson Lam, Emad Gad
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

A macro-element based practical model for seismic analysis of steel-concrete composite high-rise buildings [PDF]

, 2013
This is the post-print version of the final paper published in Engineering Structures. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting,
Li, G, Zhou, X
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Structural Control Strategies for Earthquake Response Reduction of Buildings [PDF]

, 2015
Destructive seismic events continue to demonstrate the importance of mitigating these hazards to building structures. To protect buildings from such extreme dynamic events, structural control has been considered one of the most effective strategies ...
Asai, Takehiko, Spencer, Billie F., Jr.
core  

Evaluation of structural systems in slender high-rise buildings [PDF]

, 2018
© 2018, © 2018 Engineers Australia. With the rapid population growth and scarcity of developable space, especially in large cities, there is a need for increased density in both commercial and residential housing, and hence a strong demand to maximise ...
Far, H, Patrick Walsh, Saleh, A, Walsh, P, Ali Saleh, Harry Far   +5 more
core   +1 more source

Engineering Assessment of Structural Deterioration and Preservation Challenges in a Corroded Reinforced Concrete Building Exposed to a Marine Environment

Buildings
The preservation of twentieth-century reinforced concrete buildings increasingly requires the integration of structural engineering assessment with heritage conservation principles.
Charis Apostolopoulos, Apostolos Linos Apostolopoulos, Alkiviadis Apostolopoulos   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source