Results 71 to 80 of about 6,344,239 (243)
On the use of Structural Equation Models and PLS Path Modeling to build composite indicators [PDF]
Nowadays there is a pre-eminent need to measure very complex phenomena like poverty, progress, well-being, etc. As is well known, the main feature of a composite indicator is that it summarizes complex and multidimensional issues. Thanks to its features,
Giorgio Russolillo, Laura Trinchera
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
THE MEDIATING ROLE OF DRINKING MOTIVES ON THE LINK BETWEEN ALCOHOL USE AND PERSONALITY FACTORS [PDF]
Journal of Applied Structural Equation Modeling, 2023 Rachelle Ann A. Beninsig +3 more
doaj +1 more source
Factors influencing online purchase intention of millennials and gen z consumers [PDF]
Journal of Applied Structural Equation Modeling, 2020 This study examines the factors affecting millennials and generation Z’s purchase intention in online shopping. The variables under investigation, namely, impulse purchase orientation, quality orientation, brand orientation, online trust, and online ...
Nasrul Fadhrullah Isa +3 more
doaj
Structural Equation Modeling Algorithm and Its Application in Business Analytics [PDF]
, 2017 Structural Equation Modeling (SEM) is a statistical-based multivariate modeling methods, Application of SEM is similar but more powerful than regression analysis; and number of scientists using SEM in their research is rupidly inereasing.
Shahryar Sorooshian +1 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2019 In the presence of omitted variables or similar validity threats, regression estimates are biased. Unbiased estimates (the causal effects) can be obtained in large samples by fitting instead the Instrumental Variables Regression (IVR) model.
Shi, Dexin +3 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source