Results 1 to 10 of about 4,111,048 (252)

Controlling the Substrate Specificity of an Enzyme through Structural Flexibility by Varying the Salt-Bridge Density

open access: yesMolecules, 2021
Many enzymes, particularly in one single family, with highly conserved structures and folds exhibit rather distinct substrate specificities. The underlying mechanism remains elusive, the resolution of which is of great importance for biochemistry ...
Juan Huang   +6 more
doaj   +1 more source

Discrimination of psychrophilic enzymes using machine learning algorithms with amino acid composition descriptor

open access: yesFrontiers in Microbiology, 2023
IntroductionPsychrophilic enzymes are a class of macromolecules with high catalytic activity at low temperatures. Cold-active enzymes possessing eco-friendly and cost-effective properties, are of huge potential application in detergent, textiles ...
Ailan Huang   +4 more
doaj   +1 more source

Some Clues about Enzymes from Psychrophilic Microorganisms

open access: yesMicroorganisms, 2022
Enzymes purified from psychrophilic microorganisms prove to be efficient catalysts at low temperatures and possess a great potential for biotechnological applications.
Roberta Rapuano, Giuseppe Graziano
doaj   +1 more source

Guest‐selective gate‐opening by pore engineering of two‐dimensional Kagomè lattice porous coordination polymers

open access: yesNatural Sciences, 2021
Porous coordination polymers (PCPs) with pore decoration have been used as materials for excellent storage and separation functions. The cooperative properties of flexible PCPs can be utilized to achieve the separation of mixtures of gaseous molecules ...
Mickaele Bonneau   +6 more
doaj   +1 more source

Molecular Dynamics Simulations on the Mesophilic Enzyme Vibrio Cholerae Endonuclease I: Salt Effect Study

open access: yesChemistry Proceedings, 2023
Some of the most extensively studied marine or estuarine bacteria belong to the genus Vibrio, with Vibrio cholerae being the most notorious species as it is the cause of cholera in humans. V.
Djamila Benrezkallah
doaj   +1 more source

Effect of Structural Flexibility of Wheelset/Track on Rail Wear

open access: yesLubricants, 2023
To investigate the influence of the structural deformation of the wheelset and track on rail wear in the longitudinal and lateral directions, a rail wear prediction model is established that can calculate the three-dimensional distribution of rail wear ...
Bingguang Wen   +4 more
doaj   +1 more source

Fight fire with fire: the need for a vaccine based on intrinsic disorder and structural flexibility

open access: yesExploration of Immunology, 2022
The absence of advancement in finding efficient vaccines for several human viruses, such as hepatitis C virus (HCV), human immunodeficiency virus type 1 (HIV-1), and herpes simplex viruses (HSVs) despite 30, 40, and even 60 years of research ...
Vladimir N. Uversky
doaj   +1 more source

LL-37, a Multi-Faceted Amphipathic Peptide Involved in NETosis

open access: yesCells, 2022
Innate immunity responds to infections and inflammatory stimuli through a carefully choreographed set of interactions between cells, stimuli and their specific receptors.
Marko Radic, Sylviane Muller
doaj   +1 more source

Continued Complexity of Mutations in Omicron Sublineages

open access: yesBiomedicines, 2022
The latest SARS-CoV-2 variant of concern (VOC), Omicron (B.1.1.529), has diversified into more than 300 sublineages. With an expanding number of newly emerging sublineages, the mutation profile is also becoming complicated. There exist mutually exclusive
Austin N. Spratt   +7 more
doaj   +1 more source

An Insight of RuBisCO Evolution through a Multilevel Approach

open access: yesBiomolecules, 2021
RuBisCO is the most abundant enzyme on earth; it regulates the organic carbon cycle in the biosphere. Studying its structural evolution will help to develop new strategies of genetic improvement in order to increase food production and mitigate CO2 ...
Vladimir Camel, Gaston Zolla
doaj   +1 more source

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