Results 121 to 130 of about 3,876,790 (294)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
EU Structural and Cohesion Funds in Spain and Portugal: Is Regional and National Inequality Increasing? Working Paper Series, Vol. 3 No. 11, December 2003 [PDF]
, 2003 There has been a long standing tradition within Europe that has been driven by political and economic considerations to reduce inequality and achieve convergence within Member States. To implement the “structural adjustment polices”, the attention of the
Gomis-Porqueras, Pere +1 more
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Reform of the Structural Funds after 1999. European Policy Papers #5 [PDF]
, 1997 [Introduction]. Article 2 of the Treaty on European Union (TEU) makes it clear that cohesion is one of the fundamental principles the EU seeks to respect.
Begg, Iain
core
Difficulties of the EU – the Cohesion Policy Implementation System in the Czech Republic
Czech Journal of International Relations, 2010 The article deals with the application of theories of European integration on a case study. In the first part of the article the current state of the Czech-EU structural policy is described.
Filip Capanda
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Is Structural Spending on a Solid Foundation? Bruegel Policy Brief 2008/02, February 2008 [PDF]
, 2008 Summary. The European Union’s budget review, launched last year, is an opportunity critically to examine EU policies and instruments. Structural Funds are at the heart of the EU cohesion effort, and absorb almost one third of the EU’s budget.
Santos, Indhira.
core