Results 141 to 150 of about 3,876,790 (294)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Net Inflows and Time-Varying Alphas: The Case of Hedge Funds [PDF]

The growth in the size of the hedge funds industry has led some in-vestors to worry about a decline in alphas, associated with reduced arbitrage opportunities in international financial markets.
Andrea Beltratti, Claudio Morana
core  

Redefining the Minimal Editable Unit of Supramolecular Synthons: A 1→2 Lattice-Editing Strategy in Ternary Multicomponent Crystals. [PDF]

Adv Sci (Weinh)
Lin Z, Xia H, Li M, Wang R, Wang Y, Feng X, Tang M, Zhang Y, Zhang Q.   +8 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

ACCESSING STRUCTURAL FUNDS - WAY OF RECOVERING THE TOURISM AFFECTED BY THE GLOBAL ECONOMIC CRISIS [PDF]

The tourism, as main component of national, as well as of the global economy, could not but be affected by the present financial crisis, already seen as an economic one. The effects of the worldwide crisis put their fingerprints on both components of the
Alina Gabriela Jiletcovici
core  

Seizure Freedom Despite Piriform Cortex Sparing: Structural Connectivity Remodeling After SEEG-Guided Mesial Temporal RFTC. [PDF]

Eur J Neurol
Jean S, Donkor PE, Wei X, Dai Y, Gong J, Xiao Q, Chen W, Liu W, Fang X, Song S.   +9 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Oxygen Plasma-Induced Magnetic Modulation and Air Stability Enhancement of 2D 1T-CrTe₂. [PDF]

Small
Liu J, Wang C, Sun Y, Chen C, Ji W, Xu M, Yang D.   +6 more
europepmc   +1 more source

European Structural Funds

Zeszyty Prawnicze Biura Analiz Sejmowych, 2023
openaire   +1 more source