Results 151 to 160 of about 3,876,790 (294)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

STRUCTURAL FUNDS AND OVERCOMING THE ECONOMIC CRISIS Emilian M. Dobrescu, Romanian Academy and Spiru Haret University Cristina Barna, Spiru Haret University Bucharest [PDF]

The European Commission is the authority that supervises the EuropeanUnion structural funds, which are meant to finance the measures of structural aid at thecommunity level, aiming to promote the regions lagging behind in development, toreconvert the ...
Emilian M. Dobrescu, Cristina Barna
core  

Nanoporous Metal-Organic Framework Interphase Stabilized Ni_0.6Co_0.2Mn_0.2O₂ Cathode for High-Energy Lithium Batteries. [PDF]

ChemSusChem
Yang Y, Tian Y, Deng X, Han J, Lu X, Xiu M, Wu HB.   +6 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Isomeric Dibenzodiindenophenanthrene Diradicaloids: Synthesis, Structures, Properties, and Efficient NIR Photothermal Conversion for Imaging. [PDF]

Angew Chem Int Ed Engl
Jiang Q, Zheng X, Li J, Gui Z, Luo X, Fang X, Qin Z, Zeng W, Li G, Liu L, Tan C.   +10 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

ECONOMETRIC MODEL FOR ANALYSING THE STRUCTURAL FUNDS ABSORPTION AT REGIONAL LEVEL – SECTORAL OPERATIONAL PROGRAMME HUMAN RESOURCES DEVELOPMENT [PDF]

An econometric model represents an important tool for simulating the principalmechanisms of economic systems. This could be applied at different scales, namely regional,national and international. When approaching this research field it should be kept in
Oana Gherghinescu
core  

Transformative Powder Fibration toward Hierarchical Ceramic Aerogels for Multifunctional Aerospace Systems. [PDF]

Adv Mater
Li Y, Chen L, Zhu L, Wang H, Xiang X, Kang M, Yang Y, Chen C, Sun Q.   +8 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Understanding the Mental Health Impacts of Climate Change in South Africa: Qualitative Insights From Researchers, Practitioners, Ethicists, and Funders on the Need for a Transdisciplinary Approach. [PDF]

Health Sci Rep
Tomita A, Nyoni P, Mlay J, Garlick J, Gcaba RG, Maphumulo T, Chauke H, Lessells R, Nyamwanza A.   +8 more
europepmc   +1 more source