Results 81 to 90 of about 813,020 (358)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Does EU Cohesion Policy Promote Growth? Evidence from Regional Data and Alternative Econometric Approaches [PDF]

open access: yes
This paper analyses the growth e®ects of EU structural funds using a new panel dataset of 124 NUTS-1 / NUTS-2 regions over the time period 1995-2005. We extend the current literature with regard to at least three aspects: First of all, we extend the time
Hagen, Tobias, Mohl, Philipp
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

APPEARANCE ON EUROPEAN UNION POLICY ON FUNDING SOCIO-ECONOMIC DEVELOPMENT [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2015
In the last years of the current European Union will be involved less in funding developing countries and geographic areas outside it, because we need to focus on eliminating disparities and balancing standards of living in member countries, how much ...
CHIRCULESCU MARIA FELICIA
doaj  

The Assessment of the Effectiveness of the Implementation of Infrastructural Investments within the Regional Operational Programme for the Podkarpackie Province for the years 2007-2013

open access: yesІсторико-політичні проблеми сучасного світу, 2019
This article aims to assess the effects of the implementation of infrastructural investments within the Regional Operational Programme for the Podkarpackie Province for the years 2007-2013.
Войцех Ліхота
doaj   +1 more source

Which is the Right Dose of EU Cohesion Policy for Economic Growth? [PDF]

open access: yes
The current empirical literature on the impact of EU Cohesion Policy on the economic growth rates of the European regions mainly relies on functional form assumptions.
Hagen, Tobias, Mohl, Philipp
core  

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Additionality and regional development: are EU Structural Funds complements or substitutes of national Public Finance? [PDF]

open access: yes
This paper deals with the effects of the transfer of additional funds on the real economy of recipient countries, in particular the European Member States.
Chiara Del Bo   +3 more
core  

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